The Clatworthy lab is focused on human tissue immunity and houses the Cambridge Tissue Immunity Laboratory (C-TIL).
The study of human immunity has historically focused on investigating circulating cells but there is an increasing appreciation that every organ houses a range of immune cells that are adapted to tissue-specific environmental cues. C-TIL aims to use single cell genomics, advanced biological imaging and pre-clinical models to deliver critical new insights into how immune responses are generated within organs, both in homeostasis and disease.
Fitzpatrick Z, Frazer G, Ferro A, Clare S, Bouladoux N, Ferdinand JR, Tuong ZW, Negro-Demontel ML, Suchanek O, Tajsic T, Harcourt K, Scott K, Bashford-Rogers R, Helmy A, Reich DS, Belkaid Y, Lawley T, McGavern DB*, Clatworthy MR*. Gut-educated IgA plasma cells defend meningeal venous sinuses. Nature. 2020; Nov;587(7834):472-476.
Stewart BJ^, Ferdinand JR^, Young MD, Mitchell TJ, Loudon KW, Riding AM, Richoz N, Frazer GL, Staniforth JU, Vieira Braga FA, Botting R, Popescu DM, Vento-Tormo R, Stephenson E, Cagan A, Farndon SJ, Polanski K, Efremova M, Green K, Velasco-Herrera M, Guzzo C, CollorD G, Mamanova L, Aho T, Armitage JN, Riddick AC, Mushtaq I, Farrell S, Rampling D, Nicholson J, Filby A, Burge J, Lisgo S, Lindsay S, Bajenoff M, Warren AY, Stewart GD, Sebire N, Coleman N, Haniffa M*, Teichmann SA*, Behjati S*, Clatworthy MR*. Spatio-temporal immune zonation of the human kidney. Science. 2019;365(6460):1461-1466.
Castro-Dopico T, Dennison TW, Ferdinand JR, Mathews RJ, Fleming A, Clift D, Stewart BJ, JingC, StrongiliK, Labzin LI, Monk EJM, Saeb-Parsy K, Bryant CE, Clare S, Parkes M, Clatworthy MR. Anti-commensal IgG drives intestinal inflammation and type 17 immunity. Immunity. 2019 Apr 16;50(4):1099-1114
Berry MR, Mathews RJ, Ferdinand JR, Jing C, Loudon KW, Wlodek E, Dennison TW, Kuper C, Neuhofer W, Clatworthy MR. Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone. Cell. 2017;170(5):860-74.