Our overarching goal is to understand the molecular and cellular mechanisms of host immunity and viral and bacterial pathogenesis. We use diverse approaches that span structural, molecular, optical, chemical, and cellular biology, and utilise forward and reverse genetics to explore host susceptibility and microbial virulence. We employ cell culture based assays, primary cells and clinical samples, model organisms, and where appropriate human clinical studies, to understand key processes. Highlights of our research include how immune cells are capable of discriminating between healthy cells that we must retain and infected cells that must be eliminated, how antibody generation and function is regulated with a particular focus on improving kidney transplantation, and how specific tissue environments shape immune function and activation. We are interested in how the immune system responds to, and is sometimes subverted by, viral and bacterial pathogens. Finally we are tackling the problems of antimicrobial resistance through developing novel host-directed therapies and new antibiotics, and defining mechanisms of bacterial resistance.