Insights into the pathophysiology and risk of clinical events in vascular disease using imaging
In atherosclerosis, inflammation, neovascularisation, hypoxia and calcification are drivers of plaque destabilisation and clinical events such as myocardial infarction and stroke. Conventional x-ray angiography does not provide information about the extent of these processes in the arterial wall, and as a consequence is a poor predictor of future events.
The aim of our research is to use non-invasive imaging to answer four related questions. Firstly, can we quantify the degree of arterial inflammation? Secondly, can we track the effects of therapy on arterial inflammation? Thirdly, can we use imaging to inform about the biology of arterial disease, and finally, can imaging improve our predictions about the risk of future clinical events?
Rajani NK, Joshi NV, Elkhawad M, Melville A, Chowdhury M, Ganeshan B, et al. RUDD, J. H. F. (2014) CT textural analysis of abdominal aortic aneurysms as a biomarker for aneurysm growth. The Lancet. Feb 26;383, Supplement 1(0):S87 doi: 10.1016/S0140-6736(14)60350-0
Kotze, C. W., RUDD, J. H. F, Ganeshan, B., Menezes, L. J., Brookes, J., Agu, O., . . . Groves, A. M. (2014). CT signal heterogeneity of abdominal aortic aneurysm as a possible predictive biomarker for expansion.. Atherosclerosis, 233(2), 510-517. doi:10.1016/j.atherosclerosis.2014.01.001
Dweck, M. R., Jenkins, W. S., Vesey, A. T., Pringle, M. A., Chin, C. W., Malley, T. S., . . .RUDD, J. H. F, Newby, D. E. (2014). 18F-NaF Uptake Is a Marker of Active Calcification and Disease Progression in Patients with Aortic Stenosis.. Circ Cardiovasc Imaging. doi:10.1161/CIRCIMAGING.113.001508
Bucerius, J., Mani, V., Wong, S., Moncrieff, C., Izquierdo-Garcia, D., Machac, J., . . . RUDD, J. H. F,* Fayad, Z. A.* (2014). Arterial and fat tissue inflammation are highly correlated : a prospective (18)F-FDG PET/CT study.. Eur J Nucl Med Mol Imaging. doi:10.1007/s00259-013-2653-y