Insights into the pathophysiology and risk of clinical events in vascular disease using imaging.
In atherosclerosis, inflammation, neovascularisation, hypoxia and calcification are drivers of plaque destabilisation and clinical events such as myocardial infarction and stroke. Conventional x-ray angiography does not provide information about the extent of these processes in the arterial wall, and as a consequence is a poor predictor of future events.
The aim of our research is to use non-invasive imaging to answer four related questions. Firstly, can we quantify the degree of arterial inflammation? Secondly, can we track the effects of therapy on arterial inflammation? Thirdly, can we use imaging to inform about the biology of arterial disease, and finally, can imaging improve our predictions about the risk of future clinical events?
Tarkin, J. M., Dweck, M. R., Evans, N. R., Takx, R. A., Brown, A. J., Tawakol, A., . . . RUDD, J. H. (2016). Imaging Atherosclerosis.. Circulation Research 118(4), 750-769. doi:10.1161/CIRCRESAHA.115.306247
Irkle, A., Vesey, A. T., Lewis, D. Y., Skepper, J. N., Bird, J. L., Dweck, M. R., . . . RUDD, J. H., Davenport, A. P. (2015). Identifying active vascular microcalcification by (18)F-sodium fluoride positron emission tomography. Nature Commun., 6, 7495. doi:10.1038/ncomms8495
Rajani NK, Joshi NV, Elkhawad M, Melville A, Chowdhury M, Ganeshan B, et al. RUDD, J. H. F. (2014) CT textural analysis of abdominal aortic aneurysms as a biomarker for aneurysm growth. The Lancet. Feb 26;383, Supplement 1(0):S87 doi: 10.1016/S0140-6736(14)60350-0