- The role of TGF-beta superfamily signalling in cardiovascular and pulmonary development and disease
- The mechanism underlying mammalian pluripotency and direct nuclear programming
- The translation of pluripotent stem and progenitor cells for viable cell and gene therapies.
Our lab’s interests are concerned with understanding the cellular and genetic mechanisms that underlie cell-fate decisions during (a) the embryogenesis, maintenance and repair/regeneration of the cardiovascular and pulmonary systems and (b) direct nuclear programming of somatic cells to pluripotency and cardiovascular/pulmonary fates.
Argasinska J*, RanaAA*, Gilchrist MJ, Lachani K, Young AC and Smith JC. Loss of REEP4 causes neural and muscle degeneration during Xenopus development. International Journal of Developmental Biology53(1):37-43 (2009)
SevillaLM*, RanaAA*, WattFM and Smith JC. Kazrin regulates keratinocyte intercellular adhesion, terminal differentiation and Xenopus ectodermal integrity. Developmental Dynamics Jun;237(6):1718-25 (2008)