***If you are a recent non-clinical graduate from the UK or EEA, are thinking of applying to do a PhD and have an interest in 3D bone shape and structure, funded travel to Iceland and working out better ways of diagnosing painful hip osteoarthritis (see here), please get in touch with me by email***
Research in the bone group focuses on osteoporotic fragility fractures and osteoarthritis by examining bone structure, shape and biology in health and disease. With scientists from the University Engineering for Clinical Practice initiative, we pioneered a way of assessing the 3D structure and shape of cortical bone structure in life called Cortical Thickness Mapping (CTM). We have used CTM to identify patches of focal osteoporosis in the femurs of women with hip fracture, and discovered that 1-34 parathyroid hormone therapy in severely osteoporotic women makes the femoral cortex thicker in key areas at risk of fracture. We recently discovered that cortical thickness and mass increased at critical locations in osteoporotic women treated with anti-RANK ligand antibody injections. Within the Department of Medicine, we represent the Division of Rheumatology and within Cambridge NIHR Biomedical Research Centre we represent the ‘Metabolism, Endocrinology and Bone‘ theme.
Johannesdottir F, Poole KE, Reeve J, Siggeirsdottir K, Aspelund T, Mogensen B, Jonsson BY, Sigurdsson S, Harris TB, Gudnason VG, Sigurdsson G. Distribution of cortical bone in the femoral neck and hip fracture: A prospective case-control analysis of 143 incident hip fractures; the AGES-REYKJAVIK Study. Bone 2011; 48:1268-1276.