Professor Peacock’s research focuses on the role of sequencing technologies in diagnostic microbiology and public health. A UKCRC Translational Infection Research Initiative grant of 3.2M funds the Cambridge UKCRC Consortium to develop tools that interpret genome sequence of Staphylococcus aureus and provide web-based platforms for use by public health organizations, diagnostic laboratories and healthcare workers. A Health Innovation Challenge Fund of 4.6M is being used to extend these tools to a range of other human pathogens, and to introduce microbial sequencing into routine clinical practice. Additional projects are examining the spread of antimicrobial resistance between livestock and man, and the automated interpretation of TB and other genomes to provide a rapid prediction of antimicrobial resistance. Sharon Peacock also has extensive collaborations with Mahidol University in Thailand, where her major research interest is melioidosis.
Tong SY, Holden MT, Nickerson EK, Cooper BS, Köser CU, Cori A, Jombart T, Cauchemez S, Fraser C, Wuthiekanun V, Thaipadungpanit J, Hongsuwan M, Day NP, Limmathurotsakul D, Parkhill J, Peacock SJ. Genome sequencing defines phylogeny and spread of methicillin-resistant Staphylococcus aureus in a high transmission setting. Genome Res. 2015; 25:111-8.
Chetchotisakd P, Chierakul W, Chaowagul W, Anunnatsiri S, Phimda K, Mootsikapun P, Chaisuksant S, Pilaikul J, Thinkhamrop B, Piphitaporn S, Susaengrat W, Toondee C, Wongrattanacheewin S, Wuthiekanun V, Thaipadungpanit J, Day NP, Limmathurotsakul D, Peacock SJ. Trimethoprim-sulphamethoxazole versus trimethoprim-sulphamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): a multicentre, double-blind, non-inferiority, randomised controlled trial. Lancet. 2014;383:807-814.
Uhlemann AC, Dordel J, Knox J, Raven KE, Parkhill J, Holden MT, Peacock SJ, Lowy FD. Molecular tracing of the emergence, diversification, and transmission of S. aureus sequence type 8 in a New York community. Proc Natl Acad Sci USA. 2014;111:6738-43.