My research focuses on the role of sequencing technologies in diagnostic microbiology and public health. This follows a study demonstrating for the first time that whole genome sequencing of methicillin-resistant Staphylococcus aureus (MRSA) could define transmission pathways at both global and local levels. A UKCRC Translational Infection Research Initiative grant of 3.2M has funded the development of a Cambridge UKCRC Consortium to develop tools that interpret genome sequence and provide user-friendly web-based platforms for use by public health organizations, diagnostic laboratories and healthcare workers. This will be developed to study global, national and regional transmission pathways of major drug-resistant bacterial pathogens.
Köser CU, Bryant JM, Becq J, Török ME, Ellington MJ, Marti-Renom MA, Carmichael AJ, Parkhill J, Smith GP, Peacock SJ. Whole-genome sequencing for rapid susceptibility testing of M. tuberculosis. New Engl J Med. 2013;369:290-292.
Köser CU, Holden MTG, Ellington MJ, D.Phil., Cartwright EJP, Brown NM, Ogilvy-Stuart AL, Hsu LY, Chewapreecha C, Croucher NJ, Harris SR, Sanders M, Enright MC, Dougan G, Bentley SD, Parkhill J, Fraser LJ, Betley JR, Schulz-Trieglaff OB, Smith GP, Peacock SJ. A neonatal MRSA outbreak investigation using rapid whole genome sequencing. New Engl J Med. 2012;363:2267-2275.
Harris SR, Cartwright EJP, Török ME, Holden MT, Brown NM, Ogilvy-Stuart AL, Ellington MJ, Quail MA, Bentley SD, Parkhill J, Peacock SJ. Whole-genome sequencing for analysis of an outbreak of meticillin-resistant Staphylococcus aureus: a descriptive study. Lancet Infect Dis. 2013;13:130-6.