Proteins destined for secretion or for insertion into the cell membrane are first folded within the endoplasmic reticulum. The process of protein folding can become defective in many disease states such as hypoxia, malignancy and some forms of diabetes. When the level of misfolded proteins within the endoplasmic reticulum increases, the cell is said to experience “endoplasmic reticulum stress”.
We wish to understand the cellular consequences of endoplasmic reticulum stress; in particular its effects on tissue growth and cell survival. In doing so, we hope to identify targets for the development of novel therapies. [Read More...]
Coordinate regulation of eIF2α phosphorylation by dPPP1R15 and dGCN2 is required during development. Malzer E, Szajewska-Skuta M, Dalton LE, Thomas SE, Hu N, Skaer H, Lomas DA, Crowther DC, Marciniak SJ. J Cell Sci. 2013 Feb 15. [Epub ahead of print]
The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma.Dalton LE, Clarke HJ, Knight J, Lawson MH, Wason J, Lomas DA, Howat WJ, Rintoul RC, Rassl DM, Marciniak SJ.Br J Cancer. 2013 Feb 14. doi: 10.1038/bjc.2013.66. [Epub ahead of print]
p53 and translation attenuation regulate distinct cell cycle checkpoints during ER stress.Thomas SE, Malzer E, Ordonez A, Dalton LE, van ‘t Wout EF, Liniker E, Crowther DC, Lomas DA, Marciniak SJ.J Biol Chem. 2013 Jan 22. [Epub ahead of print]