We are interested in how dysfunction of BMP signalling pathways leads to cardiovascular diseases. We study the molecular recognition between the BMPs and their receptors/co-receptors using protein crystallography and a range of biochemical, biophysical and cellular assays. In particular we aim to develop therapeutic reagents targeting PAH and HHT by manipulating these signalling complexes.
Li W, Johnson, DJD, Esmon, CT, Huntington, JA (2004) Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nature Structural & Molecular Biology. 11, 857-62.