We work on viruses and viral vectors. We are interested in the molecular and structural biology of how RNA viruses package their genetic material and how they select their own RNA from the cell so specifically. We focus on lentiviruses like HIV, the cause of AIDS. We also use lentiviruses as vectors for gene delivery and collaborate with other Departments working towards genetic treatments for disease.
Functional characterization of late outgrowth endothelial progenitor cells in patients with end-stage renal failure. Zhao J, Bolton EM, Randle L, Bradley JA, Lever AM. Transpl Int. 2014 May;27(5):437-51. doi: 10.1111
Targeting RNA-protein interactions within the human immunodeficiency virus type 1 lifecycle. Bell NM, L'Hernault A, Murat P, Richards JE, Lever AM, Balasubramanian S. Biochemistry. 2013 Dec 23;52(51):9269-74. doi: 10.1021
In-gel probing of individual RNA conformers within a mixed population reveals a dimerization structural switch in the HIV-1 leader. Kenyon JC, Prestwood LJ, Le Grice SF, Lever AM. Nucleic Acids Res. 2013 Oct;41(18):e174. doi: 10.1093