We investigate mechanisms that underlie inflammation at mucosal surfaces. We have a special interest in inflammatory bowel disease (IBD) and its related conditions, e.g. primary sclerosing cholangitis.
By interrogating the role of the intestinal epithelium we study the most ancient part of innate immunity, as it forms the interface between the body’s most abundant, diverse, and potentially hostile microbial habitat and the sterile host environment.
Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EE, Higgins DE, Schreiber S, Glimcher LH, Blumberg RS. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 2008;134:743-56.[article featured in: Clevers H. N Engl J Med 360:726-727, 2009; Leavy O. Nat Rev Immunol 8:824, 2008]
Kaser A, Hava DL, Dougan SK, Chen Z, Zeissig S, Brenner MB, Blumberg RS. Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules. Eur J Immunol. 2008;38:2351-9.