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We investigate mechanisms that underlie inflammation at mucosal surfaces. We have a special interest in inflammatory bowel disease (IBD) and its related conditions, e.g. primary sclerosing cholangitis.

By interrogating the role of the intestinal epithelium we study the most ancient part of innate immunity, as it forms the interface between the body’s most abundant, diverse, and potentially hostile microbial habitat and the sterile host environment.

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Selected References

Adolph TE†, Tomczak MF†, Niederreiter L†, Ko H-J†, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T,Billmann-Born S, Raine T, Bharti R,Lucius R,Kweon M-N, Marciniak SJ,Choi A, Hagen SJ,Schreiber S, Rosenstiel P, Kaser A* & Blumberg RS*. Paneth cells as a site of origin for intestinal inflammation Nature (2013) doi:10.1038/nature12599 Published online 02 October 2013 † shared first authors, * shared senior and communicating authors

Niederreiter L, Fritz TMJ, Adolph TE, Krismer A-M, Offner FA, Tschurtschenthaler M, Flak, MB, Hosomi, S, Tomczak MF, Kaneider NC, Sarcevic E, Kempster SL, Raine T, Esser, D, Roaenstiel P, Kohno K, Iwawaki T, Tilg H, Blumberg RS & Kaser A. ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells J Exp Med 2013; 210 (10): 2041

Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EE, Higgins DE, Schreiber S, Glimcher LH, Blumberg RS. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 2008;134:743-56.[article featured in: Clevers H. N Engl J Med 360:726-727, 2009; Leavy O. Nat Rev Immunol 8:824, 2008]

Zeissig S, Murata K, Sweet L, Publicover J, Hu Z, Kaser A, Bosse E, Iqbal J, Hussain MM, Balschun K, Röcken C, Arlt A, Günther R, Hampe J, Schreiber S, Baron JL, Moody DB, Liang TJ, Blumberg RS. Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity. Nat Med. 2012 Jul;18(7):1060-8.

Kaser A, Zeissig S, Blumberg RS. Inflammatory bowel disease. Annu Rev Immunol. 2010;28:573-621.

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