Our immune system helps us stay healthy even though we are constantly exposed to harmful bacteria and viruses. This system is a network of white blood cells and proteins that constantly surveys our body and, on encountering signs of attack, will start to eliminate the infection. This decision to act must be made with care; a weak response may lead to uncontrolled disease, but over-activity could cause an unwanted response to our own cells, as in auto-immune diseases like arthritis or multiple sclerosis.
JR James & RD Vale Biophysical mechanism of T cell receptor triggering in a reconstituted system Nature (2012) 487:64-9
JR James et al. The T cell receptor triggering apparatus is composed of monovalent or monomeric proteins J Biol Chem (2011) 286:31993-2001
JR James et al. Single molecule-level analysis of the subunit composition of the T-cell receptor on live T cells Proc Natl Acad Sci (2007) 104:17662-7
JR James, MI Oliveira, AM Carmo, A Iaboni & SJ Davis A rigorous experimental framework for detecting protein oligomerization using bioluminescence resonance energy transfer Nat Methods (2006) 3:1001-6