My research involves the study of pathways that control the expression of key cytokines that are involved in the inflammatory response. Understanding how these molecules are regulated provides insight into mechanisms that cause damage and disease during infection and disease states resulting in arthritis and cardiovascular dysfunction.
Intracellular pathogens such as Chlamydia trachomatis are exquisitely adapted to exist and manipulate the host cells environment for its own benefit and survival. Work funded by the MRC has enabled my laboratory to provide insight into how Chlamydia interacts with the host cells and regulates inflammatory processes. My award of a Senior Fellowship by Arthritis Research UK in 2011 has enabled me to investigate the role of ER stress pathways in inflammation and arthritis and identify critical molecules that regulate the expression of pro-inflammatory cytokines such as IL-23.
TSLP production by dendritic cells is modulated by IL-1β and components of the endoplasmic reticulum stress response. Matthew J. Elder, Steven J. Webster, David L. Williams, J. S. Hill Gaston, Jane C. Goodall. European J Imunol. In Press
TCR usage, gene expression and function of two distinct FOXP3+Treg subsets within CD4+CD25hiT cells identified by expression of CD39 and CD45RO. Ye L, Goodall JC, Zhang L, Putintseva EV, Lam B, Jiang L, Liu W, Yin J, Lin L, Li T, Wu X, Yeo G, Shugay M, Chudakov DM, Gaston H, Xu H. Immunol Cell Biol. 2015 Oct 15. doi: 10.1038/icb.2015.90. [Epub ahead of print]
The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress. van Galen P, Kreso A, Mbong N, Kent DG, Fitzmaurice T, Chambers JE, Xie S, Laurenti E, Hermans K, Eppert K, Marciniak SJ, Goodall JC, Green AR, Wouters BG, Wienholds E, Dick JE. (2014) Nature. 510(7504):268-72. 510, 268-272 (2014).
ER stress signals are integrated by dendritic cells to enhance IL-23 responses to Toll-like receptor .Goodall, JC., Changxin W., Zhang, Y., Ellis, L. O’Brien., L. Saudek, V and Gaston, JSH. PNAS, 12;107(41):17698-703
Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis. Shen, H., Goodall, J. and Gaston J.S.H. (2009). Arthritis and Rheumatism. 60:1647-56.
Frequency and Phenotype of T Helper 17 Cells in Peripheral Blood and Synovial Fluid of Patients with Reactive Arthritis. Shen H, Goodall JC, Gaston JS. (2010 J Rheumatol . Gaston JS. Jarvis LB, Zhang L, Goodall JC.
Dendritic cell:T cell interactions in spondyloarthritis. (2009). Adv Exp Med Biol. 649:263-76.
Does HLA-B27 modify the monocyte inflammatory response to LPS. Rheumatology 46:232-237. Goodall, JC., Ellis, L. Yeo, G.S.H and J.S.H Gaston. (2007).
Spondyloarthritis-associated and non-spondyloarthritis associated B27 subtypes differ in their dependence upon tapasin for surface expression and their incorporation into the peptide loading complex.Goodall, J.C., Ellis, L. and Gaston, J.S.H. (2005). Arthritis and Rheumatism 54, 138-147.