The Respiratory Medicine Division has six main areas of research: granulocyte biology and trafficking, the structure and function of alpha1-antitrypsin and related serpins, the genetic and molecular basis of pulmonary hypertension, the immunopathology of allergic diseases, the control of antigen processing by dendritic cells and the molecular mechanisms of ER stress.
- Professor Chilvers’, Dr Condliffe’s and Dr Parfrey’s interests relate to granulocyte cell biology, in particular, mechanisms underlying neutrophil priming, activation and apoptosis. The group also has an interest in TNFα and hypoxia signaling and neutrophil and eosinophil trafficking in vivo.
- Professor Lomas’ group works on the pathobiology of alpha-1-antitrypsin deficiency and the serpinopathies. They are also interested in the identification of genetic factors and protein biomarkers that relate to components of the COPD phenotype.
- Professor Morrell’s group is studying the molecular mechanisms leading to the development of idiopathic pulmonary arterial hypertension (PAH). In particular, his laboratory has elucidated the ways in which mutations in the bone morphogenetic protein type II receptor (BMPR-II), which underlie the majority of cases of familial PAH, disrupt intracellular signaling and proliferation of pulmonary vascular cells.
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