Diabetes and Endocrinology

This Division has three main areas of research:

 Dr Evans is interested in (1) how the brain detects changes in blood glucose and how this glucose-sensing interacts with peripheral metabolism, (2) how defences against hypoglycaemia may become abnormal in diabetes, (3) the effects hypoglycaemia on brain, and (4) improving the ability of patients with type 1 diabetes to manage their own diabetes through structured education and judicious use of new and innovative technology for monitoring and managing diabetes, including in collaboration with Dr Roman Hovorka and colleagues, the closed loop insulin pump systems (the “artificial pancreas”).

 Dr Gurnell’s research interests include (i) the role of nuclear hormone receptors in human disease, and genetic disorders of the hypothalamic-pituitary-thyroid axis, (ii) functional imaging in endocrine neoplasia, (iii) novel approaches to sparing hypothalamic-pituitary function in patients with sellar/parasellar tumours, and (iv) the endocrine and neural basis of financial decision making.

 Professor Chatterjee’s research interests relate to disorders of nuclear hormone synthesis and action.  We are studying several human cohorts: congenital hypothyroidism (CH) that is familial, syndromic or on a consanguineous background; Resistance to Thyroid Hormone (RTH); and lipodystrophic insulin resistance associated with PPARg gene defects.  Candidate gene and whole exome approaches are used to identify novel genetic aetiologies mediating thyroid dysgenesis or hormonogenesis and defective hormone action.  These approaches are supported by human phenotypic studies, studies in multisystem selenoprotein deficiency disorders and translation through our national diagnostic laboratory service to develop biomarkers of hormone action and therapies applicable to commoner thyroid disorders.

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