Diabetes and Endocrinology

 

 

This Division has three main areas of research:

Dr Evans is interested in (1) how the brain detects changes in blood glucose and how this glucose-sensing interacts with peripheral metabolism, (2) how defences against hypoglycaemia may become abnormal in diabetes, (3) the effects of hypoglycaemia on the brain, and (4) improving the ability of patients with type 1 diabetes to manage their own diabetes through structured education and judicious use of new and innovative technology for monitoring and managing diabetes, including in collaboration with Dr Roman Hovorka and colleagues, the closed loop insulin pump systems (the “artificial pancreas”).

Dr Gurnell’s research focuses on (i) genetic and acquired disorders of the hypothalamic-pituitary-thyroid axis, (ii) functional imaging in pituitary (11C-methionine) and adrenal (11C-metomidate) neoplasia, (iii) novel approaches to sparing hypothalamic-pituitary function in patients with sella/parasellar tumours and following cranial irradiation, and (iv) the endocrine and neural basis of financial decision making.

Professor Chatterjee’s research relates to disorders of nuclear hormone synthesis and action.  Human cohorts studied include: subjects with disorders of thyroid hormone metabolism & action including Resistance to Thyroid Hormone; and lipodystrophic insulin resistance associated with PPARg gene defects.  Candidate gene and whole exome approaches are used to identify novel genetic aetiologies, with complementary studies which define human phenotypes. The research is translated into genetic tests and biomarkers forming the basis of a national diagnostic service for rare/unusual thyroid disorders.

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