The Division has assembled a collaborative group of cardiovascular investigators who collectively provide expertise in basic, translational and clinical cardiovascular research and who employ genomics, epigenetics, high throughput sequencing, biomarker identification and validation, through to novel imaging, diagnostics and experimental medicine studies to improve patient outcomes. Atherosclerosis leading to myocardial infarction (MI) and stroke is the commonest cause of death in the UK. Inflammation, cell death (apoptosis), and cell senescence in atherosclerotic plaques are major contributors to plaque rupture and MI, and cardiomyocyte apoptosis underlies heart failure. Our research examines the causes and regulation of these processes in atherosclerosis, with a particular focus on DNA damage, and more recently the role of epigenetics in human heart failure.
Professor Ziad Mallat has recently joined the Division, with a major interest in immune regulation of atherosclerosis and aneurysm formation, and Dr Helle Jørgensen as a University Lecturer interested in epigenetic regulation of stem cell differentiation, to support the MRC-funded Cambridge Cardiovascular Consortium, a network of researchers focused on cardiovascular stem cells and development.
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