The research in the Division has five main strands: The first involves physiological imaging in traumatic brain injury (TBI), at all stages, from ictus to late outcome. Positron emission tomography (PET) and magnetic resonance imaging (MRI) in the acute phase currently address novel mechanisms of energy failure, including diffusion hypoxia, inflammation, amyloid deposition, and mitochondrial dysfunction. Late MRI imaging is used to investigate mechanisms underlying neurocognitive deficits in TBI patients. A second strand focuses on the neuro-anatomical basis of coma and consciousness, both in pathological states, and in the controlled situation of sedation induced by anaesthetic agents. Third, the Division has a growing program in translational pain research, which focuses on analgesic discovery in collaboration with experimental pharmacology and clinical genetics. The methodologies we employ in pain research include early phase clinical trials, quantitative sensory testing, functional brain imaging and genotyping. Our fourth theme focuses on leukocyte biology in acute lung injury and critical illness, and aims to understand the role of host response in both injury and repair. Finally, a growing initiative in non-linear analysis of complex large datasets will make use of the implementation of the new eHospital system at Addenbrooke’s Hospital.
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