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This Division has three main areas of research:
Dr Evans is interested in (1) how the brain detects changes in blood glucose and how this glucose-sensing interacts with peripheral metabolism, (2) how defences against hypoglycaemia may become abnormal in diabetes, (3) the effects of hypoglycaemia on the brain, and (4) improving the ability of patients with type 1 diabetes to manage their own diabetes through structured education and judicious use of new and innovative technology for monitoring and managing diabetes, including in collaboration with Dr Roman Hovorka and colleagues, the closed loop insulin pump systems (the “artificial pancreas”).
Dr Gurnell’s research focuses on (i) genetic and acquired disorders of the hypothalamic-pituitary-thyroid axis, (ii) functional imaging in pituitary (11C-methionine) and adrenal (11C-metomidate) neoplasia, (iii) novel approaches to sparing hypothalamic-pituitary function in patients with sella/parasellar tumours and following cranial irradiation, and (iv) the endocrine and neural basis of financial decision making.
Professor Chatterjee’s research relates to disorders of nuclear hormone synthesis and action. Human cohorts studied include: subjects with disorders of thyroid hormone metabolism & action including Resistance to Thyroid Hormone; and lipodystrophic insulin resistance associated with PPARg gene defects. Candidate gene and whole exome approaches are used to identify novel genetic aetiologies, with complementary studies which define human phenotypes. The research is translated into genetic tests and biomarkers forming the basis of a national diagnostic service for rare/unusual thyroid disorders.
Professor Krishna Chatterjee – Publications
Moran C*, Agostini M*, Visser WE, Schoenmakers E, Schoenmakers N, Offiah AC, Poole K, Rajanayagam O, Lyons G, Halsall M, Chrysis D, Efthymiadou A, Buchanan C, Aylwin S, Chatterjee K. Resistance to thyroid hormone caused by a mutation in thyroid hormone receptor (TR) 1 and TR2: a clinical, biochemical and genetic analysis of three related patients. Lancet Diabetes and Endocrinology 2014 Aug;2:619-26.
Bochukova E*, Schoenmakers N*, Agostini M, Schoenmakers E, Rajanayagam O, Keogh JM, Henning E, Reinemund J, Gevers E, Sarri M, Downes K, Offiah A, Albanese A, Halsall D, Schwabe J, Bain M, Lindley K, Muntoni F, Vargha-Khadem F, Dattani M, Farooqi S, Gurnell M, Chatterjee K. A Dominant Negative Mutation in the Thyroid Hormone Receptor Alpha Gene. New Engl J Med 2012 366: 243-249.
Schoenmakers E, Agostini M, Mitchell C, Schoenmakers N, Papp L, Rajanayagam O, Padidela R, Ceron-Gutierrez L, Doffinger R, Prevosto C, Luan J, Montano S, Lu J, Castanet M, Clemons N, Groeneveld M, Castets P, Karbaschi M, Aitken S, Dixon A, Williams J, Campi I, Blount M, Burton H, Muntoni F, O’Donovan D, Dean A, Warren A, Brierley C, Baguley D, Guicheney P, Fitzgerald R, Coles A, Gaston H, Todd P, Holmgren A, Khanna K, Cooke M, Semple R, Halsall D, Wareham N, Schwabe J, Grasso L, Beck-Peccoz P, Ogunko A, Dattani M, Gurnell M, Chatterjee K. Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. J Clin Invest 2010; 120:4220-4235.
Dr Mark Evans – Publications
Leelarathna L, Little SA, Walkinshaw E, Tan HK, Lubina-Solomon A, Kumareswaran K, Lane AP, Chadwick T, Marshall SM, Speight J, Flanagan D, Heller SR, Shaw JAM, Evans ML. Restoration of self-awareness of hypoglycemia in adults with long-standing type 1 diabetes: hyperinsulinemic hypoglycemic clamp sub-study results from the HypoCOMPaSS trial. Diabetes Care December 2013:36, 4063-4070.
Osundiji MA, Lam DD, Shaw JS, Yueh CY, Markkula P, Hurst P, Colliva C, Roda A, Heisler LK, Evans ML. Brain Glucose Sensors Play a Significant Role in the Regulation of Pancreatic Glucose-Stimulated Insulin Secretion. Diabetes 2012 Feb;61(2):321-8.
Hovorka RH, Kumareswaran K, Harris J, Allen JM, Elleri DE, Xing D, Collman C, Nodale M, Murphy H, Dunger DB, Amiel SA, Heller SR, Wilinska ME, Evans ML. Overnight closed loop insulin delivery in adults with type 1 diabetes; a randomised crossover study. Brit Med J 2011 Apr 13;342:d1855.
Osundiji MA, Hurst P, Moore SP, Markkula SP, Yueh C-Y, Swamy A, Hoashi S, Shaw JS, Riches CH, Heisler LK, Evans ML. Recurrent hypoglycemia increases hypothalamic glucose phosphorylation activity in rats. Metabolism 2011; 60:550-556.
Dr Mark Grunell – Publications
Kandasamy N, Hardy B, Page L, Schaffner M, Graggaber J, Powlson A, Fletcher P, Gurnell M, Coates J 2014. Cortisol shifts financial risk preferences. Proc Natl Acad Sci USA, 2014 Mar 4;111(9):3608-13.
Annamalai AK, Webb A, Kandasamy N, Elkhawad M, Moir S, Khan F, Maki-Petaja K, Gayton EL, Strey CH, O’Toole S, Ariyaratnam S, Halsall DJ, Chaudhry AN, Berman L, Scoffings DJ, Antoun NM, Dutka DP, Wilkinson IB, Shneerson JM, Pickard JD, Simpson HL, Gurnell M 2013. A Comprehensive Study of Clinical, Biochemical, Radiological, Vascular, Cardiac, and Sleep Parameters in an Unselected Cohort of Patients With Acromegaly Undergoing Presurgical Somatostatin Receptor Ligand Therapy. J Clin Endocrinol Metab, 2013 Mar;98(3):1040-50.
Annamalai AK, Gayton EL, Webb A, Halsall DJ, Rice C, Ibram F, Virgo G, Chaudhry AN, Simpson HL, Berman L, Gurnell M. Increased prevalence of gallbladder polyps in acromegaly. J Clin Endocrinol Metab 2011 Jul;96(7):E1120-5.
Coates JM, Gurnell M, Rustichini A. Second to fourth digit ratio predicts success among high-frequency financial traders. Proc Natl Acad Sci USA 2009; 106:623-628.