The main focus of my research is the pathophysiology and treatment of osteoporosis. I have a particular interest in osteoporosis secondary to conditions such as obesity, cystic fibrosis, organ transplantation and HIV infection. Using histomorphometry of bone sections obtained from iliac crest biopsies, we have examined changes in bone remodelling and structure in untreated and treated osteoporosis in order to establish the pathophysiology of bone loss.
Obesity Is Not Protective against Fracture in Postmenopausal Women: GLOW. Compston JE, Watts NB, Chapurlat R, Cooper C, Boonen S, Greenspan S, Pfeilschifter J, Silverman S, Díez-Pérez A, Lindsay R, Saag KG, Netelenbos JC, Gehlbach S, Hooven FH, Flahive J, Adachi JD, Rossini M, Lacroix AZ, Roux C, Sambrook PN, Siris ES; Glow Investigators. Am J Med. 2011 Nov;124(11):1043-50.
Risk factors for nonvertebral fracture in obese older women. Premaor MO, Ensrud K, Lui L, Parker RA, Cauley J, Hillier TA, Cummings S, Compston JE; Study of Osteoporotic Fractures.J Clin Endocrinol Metab. 2011 Aug;96(8):2414-21