The Clatworthy lab is interested in understanding how B cell activation and IgG antibody effector function is regulated in different tissues, particularly in the kidney and the gut using cellular and molecular immunology, single cells RNA Sequencing and two photon microscopy.
Current research questions:
- How can we regulate B cell activation and antibody generation in human disease?
- Which immune cells are capable of responding to IgG in the kidneys, and how is their position and function influenced by the kidney microenvironment.
- What role do IgG and FcgR play in the gastrointestinal tract?
- How does FcgR-crosslinking by IgG affect immune cell metabolism?
Stewart BS^, Ferdinand JR^, Young MD, Mitchell TJ, Loudon KW, Riding AM, Richoz N, Frazer GL, Staniforth JU, Vieira Braga FA, Botting R, Popescu DM, Vento-Tormo R, Stephenson E, Cagan A, Farndon SJ, Polanski K, Efremova M, Green K, Velasco-Herrera M, Guzzo C, CollorD G, Mamanova L, Aho T, Armitage JN, Riddick AC, Mushtaq I, Farrell S, Rampling D, Nicholson J, Filby A, Burge J, Lisgo S, Lindsay S, Bajenoff M, Warren AY, Stewart GD, Sebire N, Coleman N, Haniffa M*, Teichmann SA*, Behjati S*, Clatworthy MR*. Spatio-temporal immune zonation of the human kidney. Science. 2019;365(6460):1461-1466. Science. 2018. Aug 10;361(6402):594-599.
Castro-Dopico T, Dennison TW, Ferdinand JR, Mathews RJ, Fleming A, Clift D, Stewart BJ, JingC, StrongiliK, Labzin LI, Monk EJM, Saeb-Parsy K, Bryant CE, Clare S, Parkes M, Clatworthy MR. Anti-commensal IgG drives intestinal inflammation and type 17 immunity. Immunity. 2019 ;50(4):1099-1114. Immunity. 2019 Apr 16;50(4):1099-1114
Berry MR, Mathews RJ, Ferdinand JR, Jing C, Loudon KW, Wlodek E, Dennison TW, Kuper C, Neuhofer W, Clatworthy MR. Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone. Cell. 2017. 170(5):860-74. Cell. 2017;170(5):860-74.