The Clatworthy lab is interested in understanding how B cell activation and IgG antibody effector function is regulated in different tissues, particularly in the kidney and the gut using cellular and molecular immunology, single cells RNA Sequencing and two photon microscopy.
Current research questions:
- How can we regulate B cell activation and antibody generation in human disease?
- Which immune cells are capable of responding to IgG in the kidneys, and how is their position and function influenced by the kidney microenvironment.
- What role do IgG and FcgR play in the gastrointestinal tract?
- How does FcgR-crosslinking by IgG affect immune cell metabolism?
Castro-Dopico T, Dennison TW, Ferdinand JR, Mathews RJ, Fleming A, Clift D, Stewart BJ, Jing C, Strongili K, Labzin LI, Monk EJM, Saeb-Parsy K, Bryant CE, Clare S, Parkes M, Clatworthy MR. Anti-commensal IgG drives intestinal inflammation and type 17 immunity in ulcerative colitis. Immunity. 2019 Apr 16;50(4):1099-1114
Young M, Mitchell TJ, Vieira Braga F, Stewart BJ, Ferdinand JR, Botting R, Popescu DM, Vento R, Stephenson E, Cagan A, Loudon K, Farndon S, Velasco-Herrera M, Guzzo C, Collord G, Richoz N, Mamanova L, Aho T, Armitage J, Riddick A, Mushtaq I, Farrell S, Jackson C, Rampling D, Nicholson J, Filby A, Burge J, Lisgo S, Lindsay S, Warren A, Stewart GD, Sebire N, Coleman N, Hannifa M, Teichmann S, Clatworthy MR, Behjati S. Single renal cell transcriptomes across the human life span reveal the identity of kidney cancer cells. Science. 2018. Aug 10;361(6402):594-599.
Banham GD, Flint SM, Torpey NP, Lyons PA, Shanahan DN, Gibson A, Watson CJE, O’Sullivan AM, Chadwick JA, Foster KE, Jones RB, Devey LR, Richards A, Erwig LP, Savage CO, Smith KGC, Henderson RB, Clatworthy MR. A phase 2 Experimental Medicine Randomised Placebo Controlled Trial of Belimumab in Kidney Transplantation (BEL114424). Lancet. 2018. Jun 14. pii: S0140-6736(18)30984-X
Berry MR, Mathews RJ, Ferdinand JR, Jing C, Loudon KW, Wlodek E, Dennison TW, Kuper C, Neuhofer W, Clatworthy MR. Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone. Cell. 2017;170(5):860-74.