My group is interested in the intracellular mechanisms regulating NADPH oxidase function in neutrophils and the control of neutrophil and eosinophil survival by hypoxia and inflammatory cytokines. This work has a particular focus on the role of phosphoinositide 3-kinase and HIF-alpha isoforms in these processes. We also have a translational research programme, which uses radiolabeled autologous granulocytes (both neutrophils and eosinophils) combined with SPECT-CT to examine granulocyte kinetics, function and fate in vivo. Please read on after the link
Summers C, Singh NR, White JF, Mackenzie IM, Johnson A, Solanki C, Balan KK, Peters AM, Chilvers ER. Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in acute respiratory distress syndrome. Thorax 2014; 69:623-9.
Guck J, Chilvers ER. Mechanics meets medicine. Soft matters: a new high-throughput measurement technique by Tse et al. moves cell mechanical assessment of malignant pleural effusions closer to the clinic. Sci Transl Med. 2013;5(212): 212fs41.
Angulo-Herrera I, Vadas O, Garson F, Banham-Hall E, Plagnol V, Leahy R, Baxendale H, Coulter T, Curtis J, Wu C, Perisic O, Smith D, Fiddler C, Juss J, Cilliers D, Markelj G, Farmer G, Stephens L, Hawkins P, Abinun M, Clatworthy M, Doffinger R, Chilvers ER, Cant AJ, Kumararatne D, Okkenhaug K, Williams RL, Condliffe AM, Nejentsev S. Phosphoinositide 3-kinase delta activity mutation predisposes to infection and airway damage. Science 2013; 342:866-71.