My group is interested in the intracellular mechanisms regulating NADPH oxidase function in neutrophils and the control of neutrophil and eosinophil survival by hypoxia and inflammatory cytokines. This work has a particular focus on the role of phosphoinositide 3-kinase and HIF-alpha isoforms in these processes. We also have a translational research programme, which uses radiolabeled autologous granulocytes (both neutrophils and eosinophils) combined with SPECT-CT to examine granulocyte kinetics, function and fate in vivo. Please read on after the link

Read more