My group is interested in the intracellular mechanisms regulating NADPH oxidase function in neutrophils and the control of neutrophil and eosinophil survival by hypoxia and inflammatory cytokines. This work has a particular focus on the role of phosphoinositide 3-kinase and HIF-alpha isoforms in these processes. We also have a translational research programme, which uses radiolabeled autologous granulocytes (both neutrophils and eosinophils) combined with SPECT-CT to examine granulocyte kinetics, function and fate in vivo. For more details regarding the PIs research background read more below.
Cowburn AS, Takeda N, Boutin AT, Kim JW, Sterling J, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chilvers ER#, Johnson RS#. (#joint senior authors). Differential regulation of systemic arterial pressure by the skin: role of HIF isoforms. PNAS 2013; in press.
Angulo-Herrera I, Vadas O, Garson F, Banham-Hall E, Plagnol V, Leahy R, Baxendale H, Coulter T, Curtis J, Wu C, Perisic O, Smith D, Fiddler C, Juss J, Cilliers D, Markelj G, Farmer G, Stephens L, Hawkins P, Abinun M, Clatworthy M, Doffinger R, Chilvers ER, Cant AJ, Kumararatne D, Okkenhaug K, Williams RL, Condliffe AM#, Nejentsev S# (#joint senior authors). An inherited PIK3CD mutation increases phosphoinositide 3-kinase delta activity and predisposes to recurrent respiratory infections and bronchiectasis. Science 2013; in press.
Farahi N, Singh NR, Heard S, Loutsios C, Summers C, Solanki CK, Solanki K, Balan KK, Ruparelia P, Peters AM, Condliffe AM, Chilvers ER Use of 111-Indium-labelled autologous eosinophils to establish the in vivo kinetics of human eosinophils in healthy subjects. Blood 2012; 120: 4068-4071
Edwin Chilvers PhD, FMedSci
Professor of Respiratory Medicine
Department of Medicine
Director, Clinical Academic Training Office (CATO)
University of Cambridge School of Clinical Medicine
Addenbrooke's/CUHNHSFT and Papworth Hospitals
Hills Road, Cambridge CB2 2QQ, UK
Telephone/fax: (44) 1223 762007