Research

My group is interested in the intracellular mechanisms regulating NADPH oxidase function in neutrophils and the control of neutrophil and eosinophil survival by hypoxia and inflammatory cytokines. This work has a particular focus on the role of phosphoinositide 3-kinase and HIF-alpha isoforms in these processes. We also have a translational research programme, which uses radiolabeled autologous granulocytes (both neutrophils and eosinophils) combined with SPECT-CT to examine granulocyte kinetics, function and fate in vivo. Please read on after the link

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