The research programme aims to understand the mechanisms through which alterations in vascular cell function contribute to vascular disease and transplant rejection. The programme focuses on the role of death receptors, and in particular the inflammatory mediator tumour necrosis factor (TNF), in renal and cardiovascular disease, and how the two distinct receptors for TNF are independently regulated and mediate different cellular responses.
Al-Lamki RS, Sadler TJ, Wang J, Reid MJ, Warren AY, Movassagh M, Lu W, Mills IG, Neal DE, Burge J, Vandenebeele P, Pober JS, Bradley JR. Tumor necrosis factor receptor expression and signaling in renal cell carcinoma. Am J Pathol. 2010 Aug;177(2):943-54. Epub 2010 Jun 21.
D’Alessio A, Kluger MS, Li JH, Al-Lamki R, Bradley JR, Pober JS. Targeting of tumor necrosis factor receptor 1 to low density plasma membrane domains in human endothelial cells. J Biol Chem. 2010 Jul 30;285(31):23868-79. Epub 2010 May 28.
Dendrou CA, Plagnol V, Fung E, Yang JH, Downes K, Cooper JD, Nutland S, Coleman G, Himsworth M, Hardy M, Burren O, Healy B, Walker NM, Koch K, Ouwehand WH, Bradley JR, Wareham NJ, Todd JA, Wicker LS. Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet. 2009 Sep;41(9):1011-5. Epub 2009 Aug 23.