The main goal of the Ashcroft laboratory is to understand the key cellular mechanisms involved in oxygen sensing and hypoxia signalling in mammalian cells. In particular, we have a strong interest in the hypoxia inducible factor (HIF) family of transcription factors and their role in cancer, renal disease and cardiovascular disease.
Exploring the molecular interface between hypoxia-inducible factor signalling and mitochondria. Thomas LW, Ashcroft M. Cell Mol Life Sci. 2019 May;76(9):1759-1777. doi: 10.1007/s00018-019-03039-y.
CHCHD4 confers metabolic vulnerabilities to tumour cells though its control of the mitochondrial respiratory chain. Thomas LW, Stephen JM, Esposito C, Hoer S, Antrobus R, Ahmed A, Al-Habib H, Ashcroft M. Cancer Metab. 2019 Mar 6;7:2. doi: 10.1186/s40170-019-0194-y.
VHL-mediated regulation of CHCHD4 and mitochondrial function. Briston T., Stephen J., Thomas L.W., Esposito C., Chung Y.L., Syafruddin S., Turmaine M., Maddalena L., Greef B., Szabadkai G., Maxwell P.H., Vanharanta S. and Ashcroft M. Front Oncology (2018) 8: 388.
CHCHD4 regulates intracellular oxygenation and perinuclear distribution of mitochondria. Thomas L.W., Staples O., Turmaine M. and Ashcroft M. Front Oncology (2017) 7: 71.
News and Events
Prof Ashcroft gave the Keynote Lecture, entitled ‘Mitochondria and Hypoxia Signalling’ at the 2nd Mitochondrial Biology and Toxicology Research day hosted…
Prof Ashcroft attended the 1st ‘MITOchats’ Summer Symposium at the Max Planck Institute for Biology and Ageing in Cologne, Germany…
Prof Ashcroft gave the Patrick Pollard Lecture, entitled ‘The Mitochondrial Disulphide Relay System (DRS) in Physiology and Disease’, at the…