Research Interests

We investigate how lipid metabolism regulates T cell signalling and function during human ageing.

Funding

This research is funded by a BBSRC Discovery Fellowship.

Selected Publications

Edwards-Hicks J*, Apostolova P*, Buescher JM, Maib H, Stanczak MA, Corrado M, Klein Geltink RI, Maccari ME, Villa M, Carrizo GE, Sanin DE, Baixauli F, Kelly B, Curtis JD, Haessler F, Patterson A, Field CS, Caputa G, Kyle RL, Soballa M, Cha M, Paul H, Martin J, Grzes KM, Flachsmann L, Mitterer M, Zhao L, Winkler F, Rafei-Shamsabadi DA, Meiss F, Bengsch B, Zeiser R, Puleston DJ, O'Sullivan D, Pearce EJ, Pearce EL. Phosphoinositide acyl chain saturation drives CD8+ effector T cell signaling and function. Nat Immunol. 2023 Mar;24(3):516-530. doi: 10.1038/s41590-023-01419-y. Epub 2023 Feb 2. PMID: 36732424. *denotes equal contribution

Klein Geltink RI*, Edwards-Hicks J*, Apostolova P, O'Sullivan D, Sanin DE, Patterson AE, Puleston DJ, Ligthart NAM, Buescher JM, Grzes KM, Kabat AM, Stanczak M, Curtis JD, Hässler F, Uhl FM, Fabri M, Zeiser R, Pearce EJ, Pearce EL. Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy. Nat Metab. 2020 Aug;2(8):703-716. doi: 10.1038/s42255-020-0256-z. Epub 2020 Aug 3. PMID: 32747793. *denotes equal contribution

Edwards-Hicks J*, Su H*, Mangolini M, Yoneten KK, Wills J, Rodriguez-Blanco G, Young C, Cho K, Barker H, Muir M, Guerrieri AN, Li XF, White R, Manasterski P, Mandrou E, Wills K, Chen J, Abraham E, Sateri K, Qian BZ, Bankhead P, Arends M, Gammoh N, von Kriegsheim A, Patti GJ, Sims AH, Acosta JC, Brunton V, Kranc KR, Christophorou M, Pearce EL, Ringshausen I, Finch AJ. MYC sensitises cells to apoptosis by driving energetic demand. Nat Commun. 2022 Aug 9;13(1):4674. doi: 10.1038/s41467-022-32368-z. PMID: 35945217; PMCID: PMC9363429. *denotes equal contribution

Corrado M, Edwards-Hicks J, Villa M, Flachsmann LJ, Sanin DE, Jacobs M, Baixauli F, Stanczak M, Anderson E, Azuma M, Quintana A, Curtis JD, Clapes T, Grzes KM, Kabat AM, Kyle R, Patterson AE, Geltink RK, Amulic B, Steward CG, Strathdee D, Trompouki E, O'Sullivan D, Pearce EJ, Pearce EL. Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity. Cell Metab. 2020 Dec 1;32(6):981-995.e7. doi: 10.1016/j.cmet.2020.11.003. PMID: 33264603; PMCID: PMC7721104.

Edwards-Hicks J, Mitterer M, Pearce EL, Buescher JM. Metabolic Dynamics of In Vitro CD8+ T Cell Activation. Metabolites. 2020 Dec 28;11(1):12. doi: 10.3390/metabo11010012. PMID: 33379404; PMCID: PMC7823996.

Kelly B, Carrizo GE, Edwards-Hicks J, Sanin DE, Stanczak MA, Priesnitz C, Flachsmann LJ, Curtis JD, Mittler G, Musa Y, Becker T, Buescher JM, Pearce EL. Sulfur sequestration promotes multicellularity during nutrient limitation. Nature. 2021 Mar;591(7850):471-476. doi: 10.1038/s41586-021-03270-3. Epub 2021 Feb 24. PMID: 33627869; PMCID: PMC7969356.

Pagán AJ, Lee LJ, Edwards-Hicks J, Moens CB, Tobin DM, Busch-Nentwich EM, Pearce EL, Ramakrishnan L. mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity. Cell. 2022 Sep 29;185(20):3720-3738.e13. doi: 10.1016/j.cell.2022.08.018. Epub 2022 Sep 13. PMID: 36103894; PMCID: PMC9596383.

PubMed profile: https://pubmed.ncbi.nlm.nih.gov/?term=joy.+edwards-hicks