Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection.
Williams TL, Colzani MT, Macrae RGC, Robinson EL, Bloor S, Greenwood EJD, Zhan JR, Strachan G, Kuc RE, Nyimanu D, Maguire JJ, Lehner PJ, Sinha S, Davenport AP.
Commun Biol. 2021 Jul 29;4(1):926. doi: 10.1038/s42003-021-02453-y.PMID: 34326460

Modulating hESC-derived cardiomyocyte and endothelial cell function with triple-helical peptides for heart tissue engineering.
Colzani M, Malcor JD, Hunter EJ, Bayraktar S, Polkinghorne M, Krieg T, Cameron R, Best S, Farndale RW, Sinha S.
Biomaterials. 2020 Dec 16;269:120612. doi: 10.1016/j.biomaterials.2020.120612. Online ahead of print.PMID: 33385684

Natural Biomaterials for Cardiac Tissue Engineering: A Highly Biocompatible Solution
Qasim A. Majid, Annabelle T. R. Fricker, David A. Gregory, Natalia Davidenko, Olivia Hernandez Cruz, Richard J. Jabbour, Thomas J. Owen, Pooja Basnett, Barbara Lukasiewicz, Molly Stevens, Serena Best, Ruth Cameron, Sanjay Sinha, Sian E. Harding and Ipsita Roy

Aortic “Disease-in-a-Dish”: Mechanistic Insights and Drug Development Using iPSC-Based Disease Modeling
Hongorzul Davaapil, Deeti K. Shetty and Sanjay Sinha
Front. Cell Dev. Biol., 28 October 2020 |https://doi.org/10.3389/fcell.2020.550504

Collagen scaffolds functionalized with triple-helical peptides support 3D HUVEC culture
Jean-Daniel Malcor, Emma J Hunter, Natalia Davidenko, Daniel V Bax, Ruth Cameron, Serena Best, Sanjay Sinha, Richard W FarndaleRegenerative Biomaterials, rbaa025, https://doi.org/10.1093/rb/rbaa025 Published: 18 August 2020

Genomic profiling of human vascular cells identifies TWIST1 as a causal gene for common vascular diseases.
Nurnberg ST, Guerraty MA, Wirka RC, Rao HS, Pjanic M, Norton S, Serrano F, Perisic L, Elwyn S, Pluta J, Zhao W, Testa S, Park Y, Nguyen T, Ko YA, Wang T, Hedin U, Sinha S, Barash Y, Brown CD, Quertermous T, Rader DJ.
PLoS Genet. 2020 Jan 9;16(1):e1008538. doi: 10.1371/journal.pgen.1008538. eCollection 2020 Jan.
PMID: 31917787

BNC1 regulates cell heterogeneity in human pluripotent stem cell-derived epicardium
Laure Gambardella, Sophie A. McManus, Victoria Moignard, Derya Sebukhan, Agathe Delaune, Simon Andrews, William G. Bernard, Maura A. Morrison, Paul R. Riley, Berthold Göttgens, Nicolas Gambardella Le Novère, Sanjay Sinha. Development. 2019 Dec 13;146(24):dev174441. doi: 10.1242/dev.174441.
PMID: 31767620

Cell cycle regulators control mesoderm specification in human pluripotent stem cells.
Yiangou L, Grandy RA, Osnato A, Ortmann D, Sinha S, Vallier L.
J Biol Chem. 2019 Nov 22;294(47):17903-17914. doi: 10.1074/jbc.RA119.008251. Epub 2019 Sep 12.
PMID: 31515269

Glycoproteomic Analysis of the Aortic Extracellular Matrix in Marfan Patients.
Yin 殷晓科 X, Wanga S, Fellows AL, Barallobre-Barreiro J, Lu R, Davaapil H, Franken R, Fava M, Baig F, Skroblin P, Xing Q, Koolbergen DR, Groenink M, Zwinderman AH, Balm R, de Vries CJM, Mulder BJM, Viner R, Jahangiri M, Reinhardt DP, Sinha S, de Waard V, Mayr M.
Arterioscler Thromb Vasc Biol. 2019 Sep;39(9):1859-1873. doi: 10.1161/ATVBAHA.118.312175. Epub 2019 Jul 18.
PMID: 31315432

Identification of RBPMS as a mammalian smooth muscle master splicing regulator via proximity of its gene with super-enhancers.
Nakagaki-Silva EE, Gooding C, Llorian M, Jacob AG, Richards F, Buckroyd A, Sinha S, Smith CW.
Elife. 2019 Jul 8;8:e46327. doi: 10.7554/eLife.46327.
PMID: 31283468

Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration
Johannes Bargehr, Lay Ping Ong, Maria Colzani, Hongorzul Davaapil, Peter Hofsteen, Shiv Bhandari, Laure Gambardella, Nicolas Le Novère, Dharini Iyer, Fotios Sampaziotis, Florian Weinberger, Alessandro Bertero, Andrea Leonard, William G Bernard, Amy Martinson, Nichola Figg, Michael Regnier, Martin R Bennett, Charles E Murry, Sanjay Sinha. Nat Biotechnol. 2019 Aug;37(8):895-906. doi: 10.1038/s41587-019-0197-9. Epub 2019 Aug 2.
PMID: 31375810

Method to Synchronize Cell Cycle of Human Pluripotent Stem Cells without Affecting Their Fundamental Characteristics.
Yiangou L, Grandy RA, Morell CM, Tomaz RA, Osnato A, Kadiwala J, Muraro D, Garcia-Bernardo J, Nakanoh S, Bernard WG, Ortmann D, McCarthy DJ, Simonic I, Sinha S, Vallier L.
Stem Cell Reports. 2019 Jan 8;12(1):165-179. doi: 10.1016/j.stemcr.2018.11.020. Epub 2018 Dec 27.
PMID: 30595546

A Novel Human Pluripotent Stem Cell-Derived Neural Crest Model of Treacher Collins Syndrome Shows Defects in Cell Death and Migration.
Serrano F, Bernard WG, Granata A, Iyer D, Steventon B, Kim M, Vallier L, Gambardella L, Sinha S.
Stem Cells Dev. 2019 Jan 15;28(2):81-100. doi: 10.1089/scd.2017.0234. Epub 2018 Dec 18.
PMID: 30375284

Coupling of a specific photoreactive triple-helical peptide to crosslinked collagen films restores binding and activation of DDR2 and VWF.
Malcor JD, Juskaite V, Gavriilidou D, Hunter EJ, Davidenko N, Hamaia S, Sinha S, Cameron RE, Best SM, Leitinger B, Farndale RW.
Biomaterials. 2018 Nov;182:21-34. doi: 10.1016/j.biomaterials.2018.07.050. Epub 2018 Jul 31.
PMID: 30099278

Contributions of BMPR2 Mutations and Extrinsic Factors to Cellular Phenotypes of Pulmonary Arterial Hypertension Revealed by Induced Pluripotent Stem Cell Modeling.
Kiskin FN, Chang CH, Huang CJZ, Kwieder B, Cheung C, Dunmore BJ, Serrano F, Sinha S, Morrell NW, Rana AA.
Am J Respir Crit Care Med. 2018 Jul 15;198(2):271-275. doi: 10.1164/rccm.201801-0049LE.
PMID: 29547009

New models to study vascular mural cell embryonic origin: implications in vascular diseases.
Sinha S, Santoro MM.
Cardiovasc Res. 2018 Mar 15;114(4):481-491. doi: 10.1093/cvr/cvy005.
PMID: 29385541

Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids.
Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL 3rd, de Brito MC, Berntsen NL, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J, Bertero A, Zonneveld MCF, Pedersen MT, Pawlowski M, Valestrand L, Madrigal P, Georgakopoulos N, Pirmadjid N, Skeldon GM, Casey J, Shu W, Materek PM, Snijders KE, Brown SE, Rimland CA, Simonic I, Davies SE, Jensen KB, Zilbauer M, Gelson WTH, Alexander GJ, Sinha S, Hannan NRF, Wynn TA, Karlsen TH, Melum E, Markaki AE, Saeb-Parsy K, Vallier L.
Nat Med. 2017 Aug;23(8):954-963. doi: 10.1038/nm.4360. Epub 2017 Jul 3.
PMID: 28671689

Exposure of Induced Pluripotent Stem Cell-Derived Vascular Endothelial and Smooth Muscle Cells in Coculture to Hemodynamics Induces Primary Vascular Cell-Like Phenotypes.
Collado MS, Cole BK, Figler RA, Lawson M, Manka D, Simmers MB, Hoang S, Serrano F, Blackman BR, Sinha S, Wamhoff BR.
Stem Cells Transl Med. 2017 Aug;6(8):1673-1683. doi: 10.1002/sctm.17-0004. Epub 2017 Jun 19.
PMID: 28628273

Human Stem Cell-Derived Endothelial-Hepatic Platform for Efficacy Testing of Vascular-Protective Metabolites from Nutraceuticals.
Narmada BC, Goh YT, Li H, Sinha S, Yu H, Cheung C.
Stem Cells Transl Med. 2017 Mar;6(3):851-863. doi: 10.5966/sctm.2016-0129. Epub 2016 Oct 7.
PMID: 28297582

An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death.
Granata A, Serrano F, Bernard WG, McNamara M, Low L, Sastry P, Sinha S.
Nat Genet. 2017 Jan;49(1):97-109. doi: 10.1038/ng.3723. Epub 2016 Nov 28.
PMID: 27893734

Optimized inducible shRNA and CRISPR/Cas9 platforms for in vitro studies of human development using hPSCs.
Bertero A, Pawlowski M, Ortmann D, Snijders K, Yiangou L, Cardoso de Brito M, Brown S, Bernard WG, Cooper JD, Giacomelli E, Gambardella L, Hannan NR, Iyer D, Sampaziotis F, Serrano F, Zonneveld MC, Sinha S, Kotter M, Vallier L.
Development. 2016 Dec 1;143(23):4405-4418. doi: 10.1242/dev.138081.
PMID: 27899508

Embryological Origin of Human Smooth Muscle Cells Influences Their Ability to Support Endothelial Network Formation.
Bargehr J, Low L, Cheung C, Bernard WG, Iyer D, Bennett MR, Gambardella L, Sinha S.
Stem Cells Transl Med. 2016 Jul;5(7):946-59. doi: 10.5966/sctm.2015-0282. Epub 2016 May 18.
PMID: 27194743

Vascular Smooth Muscle Cells in Atherosclerosis.
Bennett MR, Sinha S, Owens GK.
Circ Res. 2016 Feb 19;118(4):692-702. doi: 10.1161/CIRCRESAHA.115.306361.
PMID: 26892967

Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells.
Iyer D, Gambardella L, Bernard WG, Serrano F, Mascetti VL, Pedersen RA, Sinha S, Talasila A.
Development. 2016 Mar 1;143(5):904. doi: 10.1242/dev.136143.
PMID: 26932673

Myocardin regulates vascular smooth muscle cell inflammatory activation and disease.
Ackers-Johnson M, Talasila A, Sage AP, Long X, Bot I, Morrell NW, Bennett MR, Miano JM, Sinha S.
Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):817-28. doi: 10.1161/ATVBAHA.114.305218. Epub 2015 Jan 22.
PMID: 25614278

Temporal and embryonic lineage-dependent regulation of human vascular SMC development by NOTCH3.
Granata A, Bernard WG, Zhao N, Mccafferty J, Lilly B, Sinha S.
Stem Cells Dev. 2015 Apr 1;24(7):846-56. doi: 10.1089/scd.2014.0520. Epub 2015 Feb 25.
PMID: 25539150

Directed differentiation of embryonic origin-specific vascular smooth muscle subtypes from human pluripotent stem cells.
Cheung C, Bernardo AS, Pedersen RA, Sinha S.
Nat Protoc. 2014 Apr;9(4):929-38. doi: 10.1038/nprot.2014.059. Epub 2014 Mar 27.
PMID: 24675733

Embryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical application.
Sinha S, Iyer D, Granata A.
Cell Mol Life Sci. 2014 Jun;71(12):2271-88. doi: 10.1007/s00018-013-1554-3. Epub 2014 Jan 18.
PMID: 24442477

Myocardin regulates vascular response to injury through miR-24/-29a and platelet-derived growth factor receptor-β.
Talasila A, Yu H, Ackers-Johnson M, Bot M, van Berkel T, Bennett MR, Bot I, Sinha S.
Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2355-65. doi: 10.1161/ATVBAHA.112.301000. Epub 2013 Jul 3.
PMID: 23825366

Embryological-origin-dependent differences in homeobox expression in adult aorta: role in regional phenotypic variability and regulation of NF-κB activity.
Trigueros-Motos L, González-Granado JM, Cheung C, Fernández P, Sánchez-Cabo F, Dopazo A, Sinha S, Andrés V.
Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1248-56. doi: 10.1161/ATVBAHA.112.300539. Epub 2013 Feb 28.
PMID: 23448971

Vascular disease in a dish: all the right ingredients?
Sinha S.
Circulation. 2012 Oct 2;126(14):1676-7. doi: 10.1161/CIRCULATIONAHA.112.134387.
PMID: 23027809

Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility.
Cheung C, Bernardo AS, Trotter MW, Pedersen RA, Sinha S.
Nat Biotechnol. 2012 Jan 15;30(2):165-73. doi: 10.1038/nbt.2107.
PMID: 22252507

Myocardin overexpression is sufficient for promoting the development of a mature smooth muscle cell-like phenotype from human embryonic stem cells.
Raphel L, Talasila A, Cheung C, Sinha S.
PLoS One. 2012;7(8):e44052. doi: 10.1371/journal.pone.0044052. Epub 2012 Aug 28.
PMID: 22937150

Human embryonic stem cell-derived vascular smooth muscle cells in therapeutic neovascularisation.
Cheung C, Sinha S.
J Mol Cell Cardiol. 2011 Nov;51(5):651-64. doi: 10.1016/j.yjmcc.2011.07.014. Epub 2011 Jul 24.
PMID: 21816157