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Department of Medicine

 

In Cambridge, we work with organisations of all sizes, from global pharma and biotech leaders to emerging medtech and data-driven companies, to transform cutting-edge research into new diagnostics, therapies, and technologies.

 

Key industry partnerships


Cambridge-GSK Translational Immunology Collaboration (CG-TIC)

CG-TIC combines University and GSK expertise in the science of the immune system, AI and clinical development with access to patients and their data provided by Cambridge University Hospitals. The ambition of this 5-year £53m partnership is to treat immune-related diseases more precisely with existing therapies and to rapidly develop new ones.

 



Biomarkers for RAtional Investigation for Neurological decision Support in TBI: BRaINS-TBI

Led by Dr Virginia Newcombe and collaborating with groups including Headway and UKABIF, BRAINS-TBI is a cohort study of 2048 patients with embedded RCT of ~800 patients who present to 10 UK Emergency Departments after sustaining a mild traumatic brain injury.

With funding of over £3m from NIHR, the study will utilise the UKRI Platform for TBI research (TBI-REPORTER). It aims to answer two key questions:

  1. Can blood biomarkers reduce the number of CT scans performed in the ED for mild TBI?
  2. Can Biomarkers identify patients at higher risk of long-term problems following mild TBI?

Case studies


T-Therapeutics: revolutionising the clinical landscape for cancer patients

Built on the foundations of research from Professor Allan Bradley in the University’s Department of Medicine, T-Therapeutics’ OpTiMus® platform sidesteps shortfalls in immuno-oncology by creating a near-unlimited database of optimal T cell receptors (TCRs).


I am brain aware: brain injury app to improve patient care

Supported by NIHR, Dr Virginia Newcomb and her research team are developing an evidence guided, app-based support and intervention programme called PCS-AWARE, to help patients self-manage post-concussion symptoms (PCS).


Reshaping the treatment of traumatic brain injury

Researchers led by Peter Hutchinson and David Menon have developed innovative therapies, identified novel monitoring tools, and launched an intensive care monitoring software, ICM+, to target the management of intracranial pressure, breaking the vicious cycle of brain swelling.


Lysosomal diseases: improved patient survival

Timothy Cox’s research pioneered oral substrate reduction therapy and drugs approved internationally for the treatment of Gaucher and Niemann-Pick C diseases; they reverse manifestations that cause disability and improve quality of life.


Pulmonary arterial hypertension: earlier diagnosis and treatment

Cambridge University research has led to routine genetic testing for BMPR2 pathway mutations in pulmonary arterial hypertension patients across the world, and the development of new treatments targeting the BMP pathway, commercialised through a University of Cambridge spin-out company, Morphogen-IX.


Osteoporosis: new diagnostics and treatment

Cambridge University research and advisory work has underpinned the development of a novel treatment and diagnostics that have transformed the management of osteoporosis and improved health and wellbeing of women with severe osteoporosis.


Bilitech: a revolution in treatment of biliary disorders

Co-founded by Dr Fotios Sampaziotis, Bilitech is a bleeding edge biomedical technology company which leverages a cellular therapy platform in order to advance the huge potential of organoid technology in regenerative medicine.


Protalea Bio: redefining age-related disease prevention

Led by Elena Pavlova, Protalea Bio aims to develop effective preventative treatment to halt the progression to active cancer in certain individuals at high risk and thereby prolonging healthy life.