The Mahadeva group has a long standing interest in mechanisms of pulmonary inflammation in COPD, particularly in those with alpha-1 antitrypsin deficiency. Ravi Mahadeva is a previous recipient of the European Respiratory society COPD research award 2004 and a Wellcome Trust Advanced Fellowship.
Studies with in vivo and cellular models are used to explore the link between conformational transitions of antitrypsin and pulmonary inflammation with a view to assessing new treatments.
Alam S, Wang J, Janciauskiene S, Mahadeva R.Preventing and reversing the cellular consequences of Z alpha-1 antitrypsin accumulation by targeting s4A. J Hepatol. 2012 Jul;57(1):116-24. doi: 10.1016/j.jhep.2012.02.025. Epub 2012 Mar 14
Al-Omari M, Korenbaum E, Ballmaier M, Lehmann U, Jonigk D, Manstein DJ, Welte T, Mahadeva R, Janciauskiene S. The acute phase protein, α1-antitrypsin, inhibits neutrophil calpain I and induces random migration. Molecular Medicine 2011;17(9-10):865-74
Alam S, Li Z, Janciauskiene S, Mahadeva R. Oxidation of Z α1-antitrypsin by cigarette smoke induces polymerization: a novel mechanism of early-onset emphysema. American Journal of Respiratory Cell and Molecular Biology 2011 Aug;45(2):261-9.