Reactivation of latent human cytomegalovirus (HCMV) infection following transplantation is associated with high morbidity and mortality; yet current therapies for HCMV, which target virus replicating productively, will not target latent viral genomes. There is also increasing evidence that HCMV persistence is associated with long-term diseases such as atherosclerosis, chronic graft rejection and neoplasias and, in […]
British Heart Foundation Senior Research Fellowship awarded
Dr Murray Clarke has been awarded a British Heart Foundation Senior Research Fellowship to investigate how cell type-specific necrosis drives inflammation in atherosclerosis and other chronic inflammatory diseases. Murray Clarke has previously shown that death of vascular smooth muscle cells (VSMCs) leads to unstable atherosclerotic plaques – the primary cause of heart attacks and stroke. […]
Expanding the heart and lungs of medicine
Fundraising is under way for a joint Cambridge University and Papworth Hospital Heart and Lung Research Institute – to sit alongside the anticipated new Papworth Hospital on the Cambridge Biomedical Campus – enabling a major expansion of cardiorespiratory research in Cambridge. Plans (subject to final design selection) of the Heart and Lung Research Institute […]
Autophagy when self-eating is good for you
New discoveries by Cambridge scientists about a molecular waste-disposal process that ‘eats’ bacteria are influencing the clinical management of cystic fibrosis, and could be the basis of innovative new treatments to fight off bacteria. Broken pieces of internal structures, damaged organelles and harmful clumps of proteins are all examples of the molecular detritus that […]
A novel therapy with potential for treating Parkinson’s disease
A collaboration between Professor John Sinclair (Dept of Medicine) and neuroscientists at Cambridge University has demonstrated how viruses that cross the blood/brain barrier could be exploited to slow down, or even halt, the progress of Parkinson’s and other neurodegenerative diseases. Image Pensive parent Credit: Jez atkinson from Flickr Creative Commons
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