Our Division conducts research across several main themes. One of these is physiological imaging of traumatic brain injury (TBI). Using positron emission tomography (PET), and magnetic resonance imaging (MRI) in the acute phase, we can map disease mechanisms, including ischaemia and diffusion hypoxia, inflammation, amyloid deposition, and mitochondrial dysfunction, all of which can lead to irreparable brain damage. We also use the same imaging techniques to investigate progressive pathology following TBI, to understand the neuroanatomical substrates of outcome, to study the neuro-anatomical basis of coma and disorders of consciousness, and understand mechanisms of anaesthesia. Other members of the Division are interested in leukocyte biology in acute lung injury and critical illness, with the ambition of explaining the role of host responses in both injury and repair, and utilising targeted novel interventions to improve outcomes in these contexts. Our Division also has a growing program in translational pain research, which includes early phase clinical trials, quantitative sensory testing, functional brain imaging and genotyping. These research areas are underpinned by a crosscutting research theme that addresses data science and the use of novel analytic methods such as machine learning and artificial intelligence.