Karamitros T, van Wilgenburg B, Wills M, Klenerman P, Magiorkinis G. Nanopore sequencing and full genome de novo assembly of human cytomegalovirus TB40/E reveals clonal diversity and structural variations. BMC Genomics. 2018 Aug 2;19(1):577. doi: 10.1186/s12864-018-4949-6

Grist JT, Jarvis LB, Georgieva Z, Thompson S, Kaur Sandhu H, Burling K, Clarke A, Jackson S, Wills M, Gallagher FA, Jones JL. Extracellular Lactate: A Novel Measure of T Cell Proliferation. J Immunol. 2018 Feb 1;200(3):1220-1226. doi: 10.4049/jimmunol.1700886. Epub 2017 Dec 29

Mok HP, Norton NJ, Hirst JC, Fun A, Bandara M, Wills MR, Lever AML. No evidence of ongoing evolution in replication competent latent HIV-1 in a patient followed up for two years. Sci Rep. 2018 Feb 8;8(1):2639. doi: 10.1038/s41598-018-20682-w.

Norton NJ, Fun A, Bandara M, Wills MR, Mok HP, Lever AML  Innovations in the quantitative virus outgrowth assay and its use in clinical trials. Retrovirology. 2017 Dec 21;14(1):58. doi: 10.1186/s12977-017-0381-2. Review.

Krishna BA, Poole EL, Jackson SE, Smit MJ, Wills MR, Sinclair JH. Latency-Associated Expression of Human Cytomegalovirus US28 Attenuates Cell Signaling Pathways To Maintain Latent Infection. MBio. 2017 Dec 5;8(6). pii: e01754-17. doi: 10.1128/mBio.01754-17.

Jackson SE, Sedikides GX, Okecha G, Poole EL, Sinclair JH, Wills MR. Latent Cytomegalovirus (CMV) Infection Does Not Detrimentally Alter T Cell Responses in the Healthy Old, But Increased Latent CMV Carriage Is Related to Expanded CMV-Specific T Cells. Front Immunol. 2017 Jun 26;8:733. doi: 10.3389/fimmu.2017.00733. 2017.

Joanna M. Pocock, Daniel M. L. Storisteanu, Matthew B. Reeves, Jatinder K. Juss,Mark R. Wills, Andrew S. Cowburn and Edwin R. Chilvers. Human Cytomegalovirus delays neutrophil apoptosis and stimulates the release of a pro-survival secretome. 2017 Sep 25;8:1185. doi: 10.3389/fimmu.2017.01185. eCollection 2017

Kew V, Wills M, Reeves M. HCMV activation of ERK-MAPK drives a multi-factorial response promoting the survival of infected myeloid progenitors. J Mol Biochem. 2017;6(1):13-25

van der Ploeg K, Chang C, Ivarsson MA, Moffett A, Trowsdale J, Wills MR. Modulation of Human Leukocyte Antigen-C by Human Cytomegalovirus Stimulates KIR2DS1 Recognition by Natural Killer Cells. Front Immunol. 2017 Mar 29;8:298. doi: 10.3389/fimmu.2017.00298. PMID:28424684 *Joint corresponding authors

 Kew VG, Wills MR, Reeves MB. LPS promotes a monocyte phenotype permissive for human cytomegalovirus immediate-early gene expression upon infection but not reactivation from latency. Sci Rep. 2017 Apr 11;7(1):810. doi: 10.1038/s41598-017-00999-8.

Fun A, Mok HP, Wills MR, Lever AM*. A highly reproducible quantitative viral outgrowth assay for the measurement of the replication-competent latent HIV-1 reservoir. Sci Rep. 2017 Feb 24;7:43231. doi: 10.1038/srep43231. *Joint corresponding authors

Jackson SE, Sedikides GX, Mason GM, Okecha G, Wills MR. HCMV Specific CD4+ T Cells are poly-functional and can respond to HCMV Infected Dendritic Cells in vitro. J Virol. 2017 Jan 4. pii: JVI.02128-16. doi: 10.1128/JVI.02128-16. PMID: 28053099

Lau B, Poole E, Van Damme E, Bunkens L, Sowash M, King H, Murphy E, Wills M, Van Loock M, Sinclair J. Human cytomegalovirus miR-UL112-1 promotes the down-regulation of viral immediate early-gene expression during latency to prevent T-cell recognition of latently infected cells. J Gen Virol. 2016 Sep;97(9):2387-98. doi: 10.1099/jgv.0.000546. PMID: 27411311

Lau B, Poole E, Krishna B, Sellart I, Wills MR, Murphy E, Sinclair J. The Expression of Human Cytomegalovirus MicroRNA MiR-UL148D during Latent Infection in Primary Myeloid Cells Inhibits Activin A-triggered Secretion of IL-6. Sci Rep. 2016 Aug 5;6:31205. doi: 10.1038/srep31205. PMID: 27491954

Krishna BA, Lau B, Jackson SE, Wills MR, Sinclair JH, Poole E. Transient activation of human cytomegalovirus lytic gene expression during latency allows cytotoxic T cell killing of latently infected cells. Sci Rep. 2016 Apr 19;6:24674. doi: 10.1038/srep24674. PMID: 27091512

Chen KC, Stanton RJ, Banat JJ, Wills MR. Leukocyte Immunoglobulin-Like Receptor 1-Expressing Human Natural Killer Cell Subsets Differentially Recognize Isolates of Human Cytomegalovirus through the Viral Major Histocompatibility Complex Class I Homolog UL18.J Virol. 2016 Jan 6;90(6):3123-37. doi: 10.1128/JVI.02614-15.

Poole E, Avdic S, Hodkinson J, Jackson S, Wills M, Slobedman B, Sinclair J.Latency-associated viral IL-10 encoded by human cytomegalovirus modulates cellular IL-10 and CCL8 secretion during latent infection through changes in the cellular miRNA, hsa-miR-92a. J Virol. 2014 Sep 24. pii: JVI.02424-14.

Ingolia NT, Brar GA, Stern-Ginossar N, Harris MS, Talhouarne GJ, Jackson SE, Wills MR, Weissman JS. Ribosome profiling reveals pervasive translation outside of annotated protein-coding genes. Cell Reports. 2014 Sep 11;8(5):1365-79. doi: 10.1016/j.celrep.2014.07.045.

Jackson SE, Mason GM, Okecha G, Sissons JG, Wills MR. 2014 Diverse specificities, phenotypes, and antiviral activities of cytomegalovirus-specific CD8+ T cells. J Virol. 2014 Sep;88(18):10894-908.

Gavin M Mason, Sarah Jackson, Georgina Okecha, Emma Poole, J.G. Patrick Sissons, John Sinclair and Mark R Wills.  2013. Human cytomegalovirus latency-associated proteins elicit immune-suppressive IL-10 producing CD4⁺ T cells. PlosPathogens 2013;9(10):e1003635

Mason, G. M., E. Poole, J. G. Sissons, J. H. Sinclair, and M. R. Wills. 2012. Human cytomegalovirus latency alters the cellular secretome, inducing cluster of differentiation (CD)4+ T-cell migration and suppression of effector function. Proceedings of the National Academy of Sciences of the United States of America 4;109(36):14538-43.

Bennett NJ, Ashiru O, Morgan FJ, Pang Y, Okecha G, Eagle RA, Trowsdale J, Sissons JG, Wills MR (2010) Intracellular sequestration of the NKG2D ligand ULBP3 by human cytomegalovirus J Immunol Jul 15; 185(2): 1093-102

Ashiru O, Bennett NJ, Boyle LH, Thomas M, Trowsdale J, Wills MR (2009) NKG2D ligand MICA is retained in the cis-Golgi apparatus by human cytomegalovirus protein UL142 J Virol Dec; 83(23): 12345-54

Solana R, Tarazona R, Aiello AE, Akbar AN, Appay V, Beswick M, Bosch JA, Campos C, Cantisán S, Cicin-Sain L, Derhovanessian E, Ferrando-Martínez S, Frasca D, Fulöp T, Govind S, Grubeck-Loebenstein B, Hill A, Hurme M, Kern F, Larbi A, López-Botet M, Maier AB, McElhaney JE, Moss P, Naumova E, Nikolich-Zugich J, Pera A, Rector JL, Riddell N, Sanchez-Correa B, Sansoni P, Sauce D, van Lier R, Wang GC, Wills MR, Zielinski M, Pawelec G 2012 CMV and Immunosenescence: from basics to clinics. Immun Ageing. 2012 Oct 31;9(1):23.

Ormiston, M. L., C. Chang, L. L. Long, E. Soon, D. Jones, R. Machado, C. Treacy, M. R. Toshner, K. Campbell, A. Riding, M. Southwood, J. Pepke-Zaba, A. Exley, R. C. Trembath, F. Colucci, M. Wills, J. Trowsdale, and N. W. Morrell. 2012. Impaired natural killer cell phenotype and function in idiopathic and heritable pulmonary arterial hypertension. Circulation 126: 1099-1109.

Mason, G. M., E. Poole, J. G. Sissons, J. H. Sinclair, and M. R. Wills*. 2012. Human cytomegalovirus latency alters the cellular secretome, inducing cluster of differentiation (CD)4+ T-cell migration and suppression of effector function. Proceedings of the National Academy of Sciences of the United States of America 4;109(36):14538-43. *Joint corresponding authors

Kuan, W. L., E. Poole, M. Fletcher, S. Karniely, P. Tyers, M. Wills, R. A. Barker, and J. H. Sinclair. 2012. A novel neuroprotective therapy for Parkinson’s disease using a viral noncoding RNA that protects mitochondrial complex I activity. The Journal of experimental medicine 209: 1-10.

Huang, M. M., V. G. Kew, K. Jestice, M. R. Wills, and M. B. Reeves. 2012. Efficient Human Cytomegalovirus Reactivation Is Maturation Dependent in the Langerhans Dendritic Cell Lineage and Can Be Studied using a CD14+ Experimental Latency Model. Journal of virology 86: 8507-8515.

Cano, F., H. Bye, L. M. Duncan, K. Buchet-Poyau, M. Billaud, M. R. Wills, and P. J. Lehner. 2012. The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation. The EMBO journal.

Wills, M., A. Akbar, M. Beswick, J. A. Bosch, C. Caruso, G. Colonna-Romano, A. Dutta, C. Franceschi, T. Fulop, E. Gkrania-Klotsas, et al  2011. Report from the second cytomegalovirus and immunosenescence workshop. Immunity & ageing : I & A 8: 10.

Jackson, S. E., G. M. Mason, and M. R. Wills. 2011. Human cytomegalovirus immunity and immune evasion. Virus research 157: 151-160.

Pawelec, G., A. Akbar, P. Beverley, C. Caruso, E. Derhovanessian, T. Fulop, P. Griffiths, B. Grubeck-Loebenstein, K. Hamprecht, G. Jahn, F. Kern, S. D. Koch, A. Larbi, A. B. Maier, D. Macallan, P. Moss, S. Samson, J. Strindhall, E. Trannoy, and M. Wills. 2010. Immunosenescence and Cytomegalovirus: where do we stand after a decade? Immun Ageing 7: 13.

Elizabeth K. Day,  Andrew J. Carmichael, Ineke J M ten Berge,  Edward C. P. Waller, J.G.Patrick Sissons, Mark R. Wills (2007) Rapid CD8+ T cell repertoire focusing and selection of high affinity clones in to memory following primary infection with a persistent human virus – human cytomegalovirus. J Immunol. 179(5): p. 3203-13.

Eagle, R. A., J. A. Traherne, O. Ashiru, M. R. Wills, and J. Trowsdale. 2006. Regulation of NKG2D ligand gene expression. Hum Immunol 67:159-169.

Weekes, M. P., M. R. Wills, J. G. Sissons, and A. J. Carmichael. 2006. Large HIV-specific CD8 cytotoxic T lymphocyte (CTL) clones reduce their overall size but maintain high frequencies of memory CTL following highly active antiretroviral therapy. Immunology 118:25-38.

Mark R  Wills, Omodele Ashiru, Matthew B Reeves, Georgina Okecha, John Trowsdale, Peter Tomasec, Gavin W G Wilkinson,  John Sinclair, and J.G. Patrick Sissons. (2005) Human Cytomegalovirus encodes An MHC Class I like molecule (UL142) which functions to inhibit natural killer (NK) cell lysis. J. Immunol. December; 175; 7457-7465

Andrew Carmichael and Mark Wills The Immunology of Infection. MEDICINE; 2005, 33:3-9

M. P. Weekes, M. R. Wills, J. G. P Sissons, and A J. Carmichael
Long-Term Stable Expanded Human CD4⁺ T Cell Clones Specific for Human Cytomegalovirus Are Distributed in Both CD45RA^high and CD45RO^high Populations J. Immunol., Nov 2004; 173: 5843 – 5851.

Hook CE, Telyatnikova N, Goodall JC, Braud VM, Carmichael AJ, Wills MR, Gaston JS.Effects of Chlamydia trachomatis infection on the expression of natural killer (NK) cell ligands and susceptibility to NK cell lysis. Clin Exp Immunol 138 (1): 54-60, 2004.

Gandhi MK, Wills MR, Sissons JG, Carmichael AJ. (2003) Human cytomegalovirus-specific immunity following haemopoietic stem cell transplantation. Blood Reviews, 17(4), 259-264

Gahndi MK, Wills MR, Okecha G, Day EK, Hicks R, Marcus RE, Sissons JGP and Carmichael (2003). Late diversification in the clonal composition of Human Cytomegalovirus-specific CD8+ T-cells following allogeneic stem cell transplantation. In press Blood

Sissons JG, Carmichael AJ, McKinney N, Sinclair JH, Wills MR. (2002) Human cytomegalovirus and immunopathology. Springer Semin Immunopathol. 24(2): 169-85

Wills MR, Carmichael AJ, Sissons JG. (2002)  Vaccines against persistent DNA virus infections. British Medical Bulletin. 62:125-38

Sissons JG, Bain M, Wills MR (2002) Latency and reactivation of human cytomegalovirus (2002) Journal of Infection 44(2):73-77.

Mark R. Wills, Georgina Okecha, Michael P. Weekes, Maher K. Gandhi, Patrick J. G. Sissons, and Andrew J. Carmichael (2002), Identification of Naive or Antigen-Experienced Human CD8 T Cells by Expression of Costimulation and Chemokine Receptors: Analysis of the Human Cytomegalovirus-SpecificCD8 T Cell Response. Journal of Immunology 168: 5455–5464.

Mark R Wills and J.G.Patrick Sissons (2000), Analysis of Cytotoxic T cell responses to Human Cytomegalovirus Infection. Methods in Molecular Medicine: Cytomegalovirus protocols, Humana press (Ed. John Sinclair)

Gillespie GM, Wills MR, Appay V, O’Callaghan C, Murphy M, Smith N, Sissons P, Rowland-Jones S, Bell JI, Moss PA. (2000)Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8(+) T lymphocytes in healthy seropositive donors.J Virol. 74(17):8140-50.

Wills, M. R., A. J. Carmichael, M. P. Weekes, K. Mynard, G. Okecha, , and J. G.P. Sissons. (1999) Human virus-specific CD8+ CTL clones revert from CD45RO^high to CD45RA^high  in vivo : CD45RA^high CD8+ T cells comprise both naive and memory cells. Journal of Immunology. 162(12):7080-87

Weekes, M. P.,A. J. Carmichael,  M. R. Wills, K. Mynard, , and J. G. P. Sissons. (1999). Human CD28- CD8+ T-cells contain greatly expanded functional virus-specific memory cytotoxic T-lymphocyte clones. Journal of Immunology. 162(12):7569-77

Weekes, M. P., M. R. Wills, K. Mynard, R. Hicks , J. G. P. Sissons, and A. J. Carmichael (1999). Large clonal expansions of human virus-specific memory cytotoxic T-lymphocytes in the CD57+ CD28- CD8+ T-cell populations. Immunology. 98(3):443-9

Weekes, M. P., M. R. Wills, K. Mynard, A. J. Carmichael, and J. G. P. Sissons. (1999). The memory Cytotoxic T-lymphocyte (CTL) response to Human Cytomegalovirus infection contains individual peptide-specific CTL clones which have undergone extensive expansion in vivo. Journal of Virology.  73:2099-2108.