Recent Publications:
- Stephenson, E., Reynolds, G., Botting, R.A., Calero-Nieto, F.J., Morgan, M.D., Tuong, KZ.K., Bach, K., Sungnak, W., Worlock. K. B., Yoshida, M., Kumasaka, N., Kania. K., Engelbert. J., Olabi. B., Spegarova, J.S.S., Wilson, N.K., Mende, N.M., Jardine, L., Gardner, L.C.S., Goh, I., Horsfall, D., McGrath. J., Webb, S., Mather, W.M., R.G.H., Dann, E., Huang, N., Polanski, K., Prigmore, E., Gothe, F., Scott, J., Payne, R.P., Baker, K.F., Hanrath, A.T., Schim van der Loeff, I.C.D., Barr, A.S., Sanchez-Gonzalez, A., Bergamaschi, L., Mescia, F., Barnes, J.L., Kilich, E.K., de Wilton, A., Saigal, A., Saleh, A., Janes, S.M., Smith, C.M., Gopee, N., Wilson, C., Coupland, P., Coxhead, J.M., Kiselev, V.Y., van Dongen, S., Bacardit, J., King, H.W., Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, Rostron, A.J., Simpson, A.J., Hambleton, S., Laurenti, E., Lyons, P.A., Kerstin B Meyer†, Nikolic†, M.Z., Duncan†, C.J.A., Smith†, K.G.C., Teichmann†, S.A., Clatworthy†, M.R., Marioni†, J.C., Göttgens†, B., Haniffa, †, M.” Single-cell multi-omics analysis of the immune response in COVID-19″. Nature Medicine, 2021: in press.
- Zhang, Z., Zhang, Y., He, T., Sweeney, C.L., Baris, S., Karakoc-Aydiner, E., Yao, Y., Ertem, D., Matthews, H.F., Gonzaga-Jauregui, C., Malech, H.L., Su, H., Ozen, A., Smith, K.G.C., and Lenardo, M. “Homozygous IL37 mutation associated with infantile inflammatory bowel disease”. Proceedings of the National Academy of Sciences of the United States of America, 2021. doi: ttps://doi.org/10.1073/pnas.2009217118
- Bergamaschi, L, Mescia, F., Turner, L., Hanson, A., Kotagiri, P., Dunmore, B.J., Ruffieux, H., De Sa, A., Huhn, O., Wills, M.R., Baker, S., Doffinger, R., Dougan, G., Elmer, A., Goodfellow, I.G., Gupta, R.K., Hosmillo, M., Hunter, K., Kingston, N., Lehner, P.J., Matheson, N.J., Nicholson, J.K., Petrunkina, A.M., Richardson, S., Saunders, C., Thaventhiran, J.E.D., Toonen, E.J.M., Weekes, M, P., Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR), COVID BioResource Collaboration, Toshner, M., Hess, C., Bradley, J.R., Lyons, P.A., and Smith, K.G.C. ” Early immune pathology and persistent dysregulation characterise severe COVID-19″. medRxiv, doi:10.1101/2021.01.11.20248765
- Kemp, S.A, Collier, D.A., Datir, R.P., Ferreira, I.A.T.M., Gayed, S., Jahun, A., Hosmillo, M., Rees-Spear, C., Mlcochova, P., Lumb., I.U., Roberts, D.J., Chandra, A., Temperton, N., he CITIID-NIHR BioResource COVID-19 Collaboration, The COVID-19 Genomics UK 9COG-UK) Consortium, Sharrocks, K., Blane, E., Modis, Y., Leigh, K., Briggs, J., van Gils, M., Smith, K.G.C., Bradley, J.R., Smith, C., Doffinger, R., Ceron-Gutierrez, L., Barcenas-Morales, G., Pollock, D.D., Goldstein, R.A., Smielewska, A., Skittrall, J.P., Gouliouris, T., Goodfellow, I.G., Gkrania-Klotsas, E.G., Illingworth, C.J.R., McCoy, L.E., and Gupta, R,K. “SARS-CoV-2 evolution during treatment of chronic infection”. Nature, doi:10.1038/s41586-021-03291-y.
- Collier, D.A., De Marco, A., Ferreira, I.A.T.M., Meng, B., Datir, R., Walls, A.C., Kemp, S.A., Bassi, J., Pinto, D., Fregni, C.C., Bianchi, S., Tortorici, M.A., Bowen, J., Culap, K., Jaconi, S., Cameroni, E, Snell, G., Pizzuto, M.S., Pellanda, A.F., Garzoni, C., Riva, A., The CITIID-NIHR BioResource COVID-19 Collaboration, Elmer, A., Kingston, N., Graves, B., McCoy, L.E., Smith, K.G.C., Bradley, J.R., Thaventhiran, J.J., Ceron-Gutierrez, L.L., Barcenas-Morales, G., Virgin, H.W., Lanzavecchia, A., Piccoli, L., Doffinger, R., Wills, M., Veesler, D., Corti, D., andGupta, R,K. “SARS-CoV-2 B.1.1.7 escape from mRNA vaccine-elicited neutralizing antibodies”. medRxiv, doi: doi:10.1101/2021.01.19.2124984.
- Buckland, M.S., Galloway, J.B., Fhogartaigh, C.N., Meredith, L., Provine, N.M., Bloor, S., Ogbe, A., Zelek, W.M., Smielewska, A., Yakovleva, A., Mann, T., Bergamaschi, L., Turner, L., Mescia, F., Toonen, E.J.M., Hackstein, C., Akther, H.A., Viera, V.A., Ceron-Gutierrez, L., Periselneris, J., Kiani-Alikhan, S., Grigoriadou, S., Vaghela, D., Lear, S.E., Torok, M.E., Hamilton, W.L., Stockton, J., Quick, J., Nelson, P., Hunter, M., Coulter, T.I., Devlin, L., CITIID-NIHR COVID-19 BioResource Collaboration, MRC-Toxicology Unit COVID-19 Consortium, Bradley, J.R., Smith, K.G.C., Ouwehand, W.H., Estcourt, L., Harvala, H., Roberts, D.J., Wilkinson, I.B., Screaton, N., Loman, N., Doffinger, R., Lyons, P.A., Morgan, B.P., Goodfellow, I.G., Klenerman, P., Lehner, P.J., Matheson, N.J., and Thaventhiran, J.E.D. “Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report”. Nature Communications, doi: 10.1038/s41467-020-19761-2.
- Foskolou, I.P., Barbieri, L., Vernet, A., Bargiela, D., Cunha, P.P., Velica, P., Suh, E., Pietsch, S., Matuleviciute, R., Rundqvist, H., McIntyre, D., Smith, K.G.C., and Johnson, R.S. “The S enantiomer of 2-hydroxyglutarate increases central memory CD8 populations and improves CAR-T therapy outcome in CAR-T production” Blood Advances, doi:10.1182/bloodadvances.2020002309.
- McKinney F., Cuthbertson I, Harris K.M., Smiklek, D.E., Connor, C., Manferri, G., Carr, E.J., Zamvil, S.S., and Smith K.G.C. “A subset of regulatory CD8+ Natural Killer cells predict favourable clinical outcome in relapsing multiple sclerosis.” Nature Communications, 2020. doi:10.1038/s41467-020-20594-2.
- Burren, O.S., Reales, G., Wong, L., Bowes, J., Lee, J.C., Barton, A., Lyons, P.A., Smith, K.G.C., Thomson, W., Kirk, P.D.W., and Wallace, C.E. “Genetic feature engineering enables characterisation of shared risk factors in immune-mediated diseases “. Genome Medicine, doi:10.1186/s13073-020-00797-4.
- Thaventhiran, J.E.D., Lango Allen, H., Burren O.S., Henry, J., Farmery, R., Staples, E., Zhang, Z., Rae, W., Greene, D., Simeoni, I., Penkett, C., Stephens, J., Thomas, M., Sargur, R., Gordins, P., Baxendale, H., Tuijnenburg, P., Worth, A., Hanson, S., Buckland,M.S., Gilmour, K., Maimaris, J., Lyons, P., Sansom, D.M., Lynch, A.G., Ellinghaus, E., Ellinghaus, D., Hemming Karlsen, T., Cutler, A.J., Kumararatne, D.S., NIHR Bioresource, Savic, S., Burns, S.O., Kuijpers, T.W., Ouwehand, W.H., Thrasher, A.J., and Smith, K.G.C. “Genetics of primary immunodeficiency revealed by genome sequencing a sporadic cohort.” Nature, 2020;583:90-95. doi:10.1038/s41586-020-2265-1.
- Wilson, T., Clare, S., Mikulin, J., Johnson, C., Harcourt, K., Lyons, P., Dougan, G., and Smith, K.G.C. “SLAMF9 is found on select subsets of antigen-presenting cells and promotes resistance to Salmonella infection.” Immunology, 2020;159:393-403. doi:1111/imm.13169, 16649442.
- Bonaud, A., Clare, S., Bisio, V., Sowerby, J., Yao, Y., Ostergaard, H., Balabanian, K., Smith, K.G.C., and Espéli, M. “Leupaxin expression is dispensable for B cell immune responses.” Frontiers in Immunology, 2020;11:466. doi:10.3389/fimmu.2020.00466.
- Bourges, C., Groff, A. F., Burren, O.S., Gerhardinger, C., Mattioli, K., Hutchinson, A., Hu, T., Anand, T., Epping, M. W., Wallace, C., Smith, K.G.C., Rinn, J.L., and Lee, J.C. “Resolving mechanisms of immune-mediated disease in primary CD4 T cells.” EMBO Molecular Medicine, 2020;12:e12112. doi:10.15252/emmm.202012112.
- Ortiz-Fernández, L., López-Mejias, R., Carmona, FD., Castaño-Nuñez, A.L.,Lyons, P.A., Caruz, A., Gónzalez-Escribano, M.F., Smith, K.G.C., González-Gay, M.A., Martin, J., Spanish GCA Study Group, IgAV Study Group, AAV Study Group and HIV Study Group. “The role of a functional variant of TYK2 in vasculitides and infections.” Clinical and Experimental Rheumatology, PMID: 32167874.Rivett, L., Sridhar, S., Sparkes, D., Routledge, M., Jones, N.K., Forrest, S., Young, J., Pereira-Dias, J., Hamilton, W.L., Ferris, M., Torok, E., Meredith L., the CITIID-NIHR COVID-19 BioResource Collaboration, Curran, M., Fuller, S., Chaudhry, A., Shaw, A., Samworth, R.J., Bradley, J.R., Dougan, G., Smith, K.G.C., Lehner, P.J., Matheson, N.J., Wright, G., Goodfellow, I., Baker, S., and Weekes, M.P. “Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission.” eLife, 2020;11:9:e58728. doi:10.7554/eLife.58728.
- Rajewsky, N., Almouzni, G., Gorski, S.A., Aerts, S., Amit, I., Bertero M.G., Bock, C., Bredenoord, A.L., Brooksbank, C., Cavalli, G., Chiocca, S., Clevers, H., De Strooper, B., Eggert, A., Ellenberg, J., Fernandez, X.M., Figlerowicz, M., Gasser, S.M., Hubner, N., Kjems, j., Knoblich, J.A., Krabbe, G., Lichter, P., Linnarsson, S., Marine, J., Marioni, J., Marti-Renom, M.A., Netea, M.G., Nickel, D., Nollmann, M., Novak, H.R., Parkinson, H., Piccolo, S., Pinheiro, I., Pombo, A., Popp, C., Reik, W., Roman-Roman, S., Rosenstiel, P., Schultze, J.L., Stegle, O., Tanay, A., Testa, G., Thanos, D., Theis, F., Torres-Padilla, M., Valencia, A., Vallot, C., Oudenaarden, A.V., Vidal, M., Voet, T., and LifeTime Community. “LifeTime and improving European healthcare through cell-based interceptive medicine” Nature, 2020 doi:10.1038/s41586-020-2715-9.
Publications 2010 – 2019
- Catapano, F., Chaudhry, A.N., Jones, R.B., Smith, K.G.C. and Jayne, D.W. “Long-term efficacy and safety of rituximab in refractory and relapsing systemic lupus erythematosus.” Nephrology Dialysis Transplantation, 2010;25:3586-3592. doi:10.1093/ndt/gfq256.
- Fabani, M.M., Abreu-Goodger, C., Williams, D., Lyons, P.A., Torres, A.G., Smith, K.G.C., Enright, A.J., Gait, M.J. and Vigorito, E. “Efficient inhibition of miR-155 function in vivo by peptide nucleic acids.” Nucleic Acids Research, 2010;38:4466-4475. doi:10.1093/nar/gkq160.
- Lyons, P.A., McKinney, E.F., Rayner, T.F., Hatton, A., Woffendin, H.B., Koukoulaki, M., Freeman, T.C., Jayne, D.R., Chaudhry, A.N. and Smith, K.G.C. “Novel expression signatures identified by transcriptional analysis of separated leucocyte subsets in systemic lupus erythematosus and vasculitis.” Annals of the Rheumatic Diseases, 2010;69:1208-1213. doi:10.1136/ard.2009.108043.
- McKinney, E.F., Lyons, P.A., Carr, E.J., Hollis, J.L., Jayne, D.R., Willcocks, L.C., Koukoulaki, M., Brazma, A., Jovanovic, V., Kemeny, D.M., Pollard, A.J., Macary, P.A., Chaudhry, A.N. and Smith, K.G.C. “A CD8+ T cell transcription signature predicts prognosis in autoimmune disease.” Nature Medicine, 2010;16:586-591. doi:10.1038/nm.2130.
- Niederer, H.A., Willcocks, L.C., Rayner, T.F., Yang, W., Lau, Y.L., Williams, T.N., Scott, J.A., Urban, B.C., Peshu, N., Dunstan, S.J., Hien, T.T., Phu, N.H., Padyukov, L., Gunnarsson, I., Svenungsson, E., Savage, C.O., Watts, R.A., Lyons, P.A., Clayton, D.G. and Smith, K.G.C. “Copy number, linkage disequilibrium and disease association in the FCGR locus.” Human Molecular Genetics, 2010;19:3282-3294. doi:10.1093/hmg/ddq216.
- Oracki, S.A., Tsantikos, E., Quilici, C., Light, A., Schmidt, T., Lew, A.M., Martin, J.E., Smith, K.G.C., Hibbs, M.L. and Tarlinton, D.M. “CTLA4Ig alters the course of autoimmune disease development in Lyn-/- mice.” Journal of Immunology, 2010;184:757-763. doi:10.4049/jimmunol.0804349.
- Willcocks, L.C., Carr, E.J., Niederer, H.A., Rayner, T.F., Williams, T.N., Yang, W., Scott, J.A., Urban, B.C., Peshu, N., Vyse, T.J., Lau, Y.L., Lyons, P.A. and Smith, K.G.C. “A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus.” Proceedings of the National Academy of Sciences of the United States of America, 2010;107:7881-7885. doi:10.1073/pnas.0915133107.
- Espeli, M., Bokers, S., Giannico, G., Dickinson, H.A., Bardsley, V., Fogo, A.B. and Smith, K.G.C. “Local renal autoantibody production in lupus nephritis.” Journal of the American Society of Nephrology, 2011;22:296-305. doi:10.1681/ASN.2010050515.
- Lee, J.C., Lyons, P.A., McKinney, E.F., Sowerby, J.M., Carr, E.J., Bredin, F., Rickman, H.M., Ratlamwala, H., Hatton, A., Rayner, T.F., Parkes, M. and Smith, K.G.C. “Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis.” Journal of Clinical Investigation, 2011;121:4170-4179. doi:10.1172/JCI59255.
- Linterman, M.A., Pierson, W., Lee, S.K., Kallies, A., Kawamoto, S., Rayner, T.F., Srivastava, M., Divekar, D.P., Beaton, L., Hogan, J.J., Fagarasan, S., Liston, A., Smith, K.G.C.* and Vinuesa, C.G.* (equal senior authors). “Foxp3+ follicular regulatory T cells control the germinal center response.” Nature Medicine, 2011;17:975-982. doi:10.1038/nm.2425.
- Smith, K.G.C., Willcocks, L.C. and Lyons, P.A. “Comment on “The inhibiting Fc receptor for IgG, FcgammaRIIB, is a modifier of autoimmune susceptibility”.” Journal of Immunology, 2011;187:5473. doi:10.4049/jimmunol.1101194.
- Waisberg, M., Tarasenko, T., Vickers, B.K., Scott, B.L., Willcocks, L.C., Molina-Cruz, A., Pierce, M.A., Huang, C.Y., Torres-Velez, F.J., Smith, K.G.C., Barillas-Mury, C., Miller, L.H., Pierce, S.K. and Bolland, S. “Genetic susceptibility to systemic lupus erythematosus protects against cerebral malaria in mice.” Proceedings of the National Academy of Sciences of the United States of America, 2011;108:1122-1127. doi:10.1073/pnas.1017996108.
- Callaghan, C.J., Win, T.S., Motallebzadeh, R., Conlon, T.M., Chhabra, M., Harper, I., Sivaganesh, S., Bolton, E.M., Bradley, J.A., Brownlie, R.J., Smith, K.G.C. and Pettigrew, G.J. “Regulation of allograft survival by inhibitory FcgammaRIIb signaling.” Journal of Immunology, 2012;189:5694-5702. doi:10.4049/jimmunol.1202084.
- Clatworthy, M.R., Kettunen, M.I., Hu, D.E., Mathews, R.J., Witney, T.H., Kennedy, B.W., Bohndiek, S.E., Gallagher, F.A., Jarvis, L.B., Smith, K.G.C. and Brindle, K.M. “Magnetic resonance imaging with hyperpolarized [1,4-(13)C2]fumarate allows detection of early renal acute tubular necrosis.” Proceedings of the National Academy of Sciences of the United States of America, 2012;109:13374-13379. doi:10.1073/pnas.1205539109.
- Espeli, M., Clatworthy, M.R., Bokers, S., Lawlor, K.E., Cutler, A.J., Kontgen, F., Lyons, P.A. and Smith, K.G.C. “Analysis of a wild mouse promoter variant reveals a novel role for FcgammaRIIb in the control of the germinal center and autoimmunity.” Journal of Experimental Medicine, 2012;209:2307-2319. doi:10.1084/jem.20121752.
- Kain, R., Tadema, H., McKinney, E.F., Benharkou, A., Brandes, R., Peschel, A., Hubert, V., Feenstra, T., Sengolge, G., Stegeman, C., Heeringa, P., Lyons, P.A., Smith, K.G.C., Kallenberg, C. and Rees, A.J. “High prevalence of autoantibodies to hLAMP-2 in anti-neutrophil cytoplasmic antibody-associated vasculitis.” Journal of the American Society of Nephrology, 2012;23:556-566. doi:10.1681/ASN.2011090920.
- Lyons, P.A., Rayner, T.F., Trivedi, S., Holle, J.U., Watts, R.A., Jayne, D.R., Baslund, B., Brenchley, P., Bruchfeld, A., Chaudhry, A.N., Cohen Tervaert, J.W., Deloukas, P., Feighery, C., Gross, W.L., Guillevin, L., Gunnarsson, I., Harper, L., Hruskova, Z., Little, M.A., Martorana, D., Neumann, T., Ohlsson, S., Padmanabhan, S., Pusey, C.D., Salama, A.D., Sanders, J.S., Savage, C.O., Segelmark, M., Stegeman, C.A., Tesar, V., Vaglio, A., Wieczorek, S., Wilde, B., Zwerina, J., Rees, A.J., Clayton, D.G. and Smith, K.G.C. “Genetically distinct subsets within ANCA-associated vasculitis.” New England Journal of Medicine, 2012;367:214-223. doi:10.1056/NEJMoa1108735.
- Smith, R.M., Jones, R.B., Guerry, M.J., Laurino, S., Catapano, F., Chaudhry, A., Smith, K.G.C. and Jayne, D.R. “Rituximab for remission maintenance in relapsing antineutrophil cytoplasmic antibody-associated vasculitis.” Arthritis & Rheumatology, 2012;64:3760-3769. doi:10.1002/art.34583.
- Teoh, E.P., Kukkaro, P., Teo, E.W., Lim, A.P., Tan, T.T., Yip, A., Schul, W., Aung, M., Kostyuchenko, V.A., Leo, Y.S., Chan, S.H., Smith, K.G.C., Chan, A.H., Zou, G., Ooi, E.E., Kemeny, D.M., Tan, G.K., Ng, J.K., Ng, M.L., Alonso, S., Fisher, D., Shi, P.Y., Hanson, B.J., Lok, S.M. and MacAry, P.A. “The structural basis for serotype-specific neutralization of dengue virus by a human antibody.” Science Translational Medicine, 2012;4:139ra183. doi:10.1126/scitranslmed.3003888.
- Walker, J.A., Hall, A.M., Kotsopoulou, E., Espeli, M., Nitschke, L., Barker, R.N., Lyons, P.A. and Smith, K.G.C. “Increased red cell turnover in a line of CD22-deficient mice is caused by Gpi1c: a model for hereditary haemolytic anaemia.” European Journal of Immunology, 2012;42:3212-3222. doi:10.1002/eji.201242633.
- Jovanovic, V., Abdul Aziz, N., Lim, Y.T., Ng Ai Poh, A., Jin Hui Chan, S., Ho Xin Pei, E., Lew, F.C., Shui, G., Jenner, A.M., Bowen, L., McKinney, E.F., Lyons, P.A., Kemeny, M.D., Smith, K.G.C., Wenk, M.R. and Macary, P.A. “Lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus.” PLOS One, 2013;8:e55639. doi:10.1371/journal.pone.0055639.
- Lee, J.C., Espeli, M., Anderson, C.A., Linterman, M.A., Pocock, J.M., Williams, N.J., Roberts, R., Viatte, S., Fu, B., Peshu, N., Hien, T.T., Phu, N.H., Wesley, E., Edwards, C., Ahmad, T., Mansfield, J.C., Gearry, R., Dunstan, S., Williams, T.N., Barton, A., Vinuesa, C.G., Consortium, U.I.G., Parkes, M., Lyons, P.A. and Smith, K.G.C. “Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway.” Cell, 2013;155:57-69. doi:10.1016/j.cell.2013.08.034.
- Mok, Y., Schwierzeck, V., Thomas, D.C., Vigorito, E., Rayner, T.F., Jarvis, L.B., Prosser, H.M., Bradley, A., Withers, D.R., Martensson, I.L., Corcoran, L.M., Blenkiron, C., Miska, E.A., Lyons, P.A. and Smith, K.G.C. “MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production.” Journal of Immunology, 2013;191:3037-3048. doi:10.4049/jimmunol.1301289.
- Pepper, R.J., Hamour, S., Chavele, K.M., Todd, S.K., Rasmussen, N., Flint, S., Lyons, P.A., Smith, K.G.C., Pusey, C.D., Cook, H.T. and Salama, A.D. “Leukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis.” Kidney International, 2013;83:1150-1158. doi:10.1038/ki.2013.2.
- Rivino, L., Kumaran, E.A., Jovanovic, V., Nadua, K., Teo, E.W., Pang, S.W., Teo, G.H., Gan, V.C., Lye, D.C., Leo, Y.S., Hanson, B.J., Smith, K.G.C., Bertoletti, A., Kemeny, D.M. and MacAry, P.A. “Differential targeting of viral components by CD4+ versus CD8+ T lymphocytes in dengue virus infection.” Journal of Virology, 2013;87:2693-2706. doi:10.1128/JVI.02675-12.
- Sun, J.B., Xiang, Z., Smith, K.G.C. and Holmgren, J. “Important role for FcgammaRIIB on B lymphocytes for mucosal antigen-induced tolerance and Foxp3+ regulatory T cells.” Journal of Immunology, 2013;191:4412-4422. doi:10.4049/jimmunol.1301324.
- Zilbauer, M., Rayner, T.F., Clark, C., Coffey, A.J., Joyce, C.J., Palta, P., Palotie, A., Lyons, P.A. and Smith, K.G.C. “Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type-specific hypomethylated regions.” Blood, 2013;122:e52-60. doi:10.1182/blood-2013-05-503201.
- Bokers, S., Urbat, A., Daniel, C., Amann, K., Smith, K.G.C., Espeli, M. and Nitschke, L. “Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice.” Journal of Immunology, 2014;192:2994-3002. doi:10.4049/jimmunol.1303367.
- Clatworthy, M.R., Aronin, C.E., Mathews, R.J., Morgan, N.Y., Smith, K.G.C. and Germain, R.N. “Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes.” Nature Medicine, 2014;20:1458-1463. doi:10.1038/nm.3709.
- Clatworthy, M.R., Harford, S.K., Mathews, R.J. and Smith, K.G.C. “FcgammaRIIb inhibits immune complex-induced VEGF-A production and intranodal lymphangiogenesis.” Proceedings of the National Academy of Sciences of the United States of America, 2014;111:17971-17976. doi:10.1073/pnas.1413915111.
- Clatworthy, M.R., Matthews, R., Doehler, B., Willcocks, L., Opelz, G. and Smith, K.G.C. “De-functioning polymorphism in the inhibitory receptor FcgammaRIIB does not impact upon kidney allograft survival.” Clinical and Experimental Immunology, 2014;178 Suppl 1:159-161. doi:10.1111/cei.12553.
- Clatworthy, M.R., Matthews, R.J., Doehler, B., Willcocks, L.C., Opelz, G. and Smith, K.G.C. “Defunctioning polymorphism in the immunoglobulin G inhibitory receptor (FcgammaRIIB-T/T232) does not impact on kidney transplant or recipient survival.” Transplantation, 2014;98:285-291. doi:10.1097/TP.0000000000000287.
- Ferreira, R.C., Guo, H., Coulson, R.M., Smyth, D.J., Pekalski, M.L., Burren, O.S., Cutler, A.J., Doecke, J.D., Flint, S., McKinney, E.F., Lyons, P.A., Smith, K.G.C., Achenbach, P., Beyerlein, A., Dunger, D.B., Clayton, D.G., Wicker, L.S., Todd, J.A., Bonifacio, E., Wallace, C. and Ziegler, A.G. “A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes.” Diabetes, 2014;63:2538-2550. doi:10.2337/db13-1777.
- Jones, R.B., Walsh, M., Chaudhry, A.N., Smith, K.G.C. and Jayne, D.R. “Randomized trial of enteric-coated mycophenolate sodium versus mycophenolate mofetil in multi-system autoimmune disease.” Clinical Kidney Journal, 2014;7:562-568. doi:10.1093/ckj/sfu096.
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