F.J. Roca, L.J. Whitworth, S. Redmond, A.A. Jones, L. Ramakrishnan 2019. TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit. Cell Aug https://doi.org/10.1016/j.cell.2019.08.004
Adams KN, Verma AK, Gopalaswamy R, Adikesavalu H, Singhal DK, Tripathy S, Ranganathan UD, Sherman DR, Urdahl KB, Ramakrishnan L, Hernandez RE. 2019. Diverse Clinical Isolates of Mycobacterium tuberculosis Develop Macrophage-Induced Rifampin Tolerance. J Infect Dis. Apr 19;219(10):1554-1558. https://doi: 10.1093/infdis/jiy710. Erratum in: J Infect Dis. 2019 Jun 19;220(2):342.
R.E. Hernandez, L. Galitan, J. Cameron, N. Goodwin, L. Ramakrishnan 2018. Delay of initial feeding of zebrafish larvae until 8 days postfertilization has no impact on survival or growth through the juvenile stage. Zebrafish Oct 15(5):515-518 https://doi.org/10.1089/zeb.2018.1579
M.A. Behr, P.H. Edelstein, L. Ramakrishnan 2018. Revisiting the timetable of tuberculosis. BMJ Aug 23;362:k2738 https://doi.org/10.1136/bmj.k2738
A.J. Pagan, L. Ramakrishnan 2018. The formation and function of granulomas. Annu Rev Immunol Apr 26;36:639-665 https://doi.org/10.1146/annurev-immunol-032712-100022
K. Takaki, L. Ramakrishnan, S. Basu 2018. PLoS One Mar 27;13(3):e0194982 https://doi.org/10.1371/journal.pone.0194982
C.J. Cambier, S.M. O’Leary, M.P. O’Sullivan, J. Keane, L. Ramakrishnan 2017. Phenolic Glycolipid facilitates mycobacterial escape from microbicidal tissue-resident macrophages. Immunity 47:552-565 https://doi.org/10.1016/j.immuni.2017.08.003
C. A. Madigan, J. Cameron, L. Ramakrishnan. 2017. A zebrafish model of Mycobacterium leprae granulomatous infection. J Infect Dis 16:776-779 https://doi.org/10.1093/infdis/jix329
C.A. Madigan, C.J. Cambier, K.M. Kelly-Scumpia, P.O. Scumpia, T.Y. Cheng, J. Zailaa, B.R. Bloom, D.B. Moody, S.T. Smale, A. Sagasti, R.L. Modlin, L. Ramakrishnan. 2017. A macrophage response to Mycobacterium leprae phenolic glycolipid initiates nerve damage in leprosy. Cell:170:973-985. https://doi.org/10.1016/j.cell.2017.07.030
C. Boggiano, K. Eichelberg, L.Ramachandra, J. Shea, L. Ramakrishnan, S. Behar, J.D. Ernst, S.A. Porcelli, M. Maeurer, H. Kornfeld 2017. The impact of Mycobacterium tuberculosis immune evasion of protective immunity: implications for TB vaccine design – Meeting report. Vaccine 35:3433-3440 https://doi.org/10.1016/j.vaccine.2017.04.007
N.T.T. Thuong, D. Heemskerk, T.T.B. Tram, L.T.P, Thao, L. Ramakrishnan, V.T.N. Ha, N.D. Bang, T.T.H. Chau, N.H. Lan, M. Caws, S.J. Dunstan, N.V.W. Chau, M. Wolbers, N.T.H. Mai, G.E. Thwaites 2017. Leukotriene A4 hydrolase genotype and HIV infection influence intracerebral inflammation and survival. J Infect Dis 215:1020-1028 https://doi.org/10.1093/infdis/jix050
A.J. Pagan, L. Ramakrishnan. 2017. TORmented macrophages spontaneously form granulomas. Nat Immunol 18:252-253 https://doi.org/10.1038/ni.3689
W.H. Conrad, M.M. Osman, J.K. Shanahan, F. Chu, K.K. Takaki, J. Cameron, D. Hopkinson-Woolley, R. Brosch, L. Ramakrishnan. 2017. Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions. Proc Natl Acad Sci U S A. 114:1371-1376. https://doi.org/10.1073/pnas.1620133114
S. Levitte, K.N. Adams, R.D. Berg, C.L. Cosma, K.B. Urdahl, L. Ramakrishnan. 2016. Mycobacterial Acid Tolerance Enables Phagolysosomal Survival and Establishment of Tuberculous Infection In Vivo. Cell Host and Microbe 20:250-258 https://doi.org/10.1016/j.chom.2016.07.007
R.D. Berg, S. Levitte, M.P. O’Sullivan, S.M. O’Leary, C.J. Cambier, J. Cameron, K.K. Takaki, C.B. Moens, D.M. Tobin, J. Keane, L. Ramakrishnan. 2016. Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration. Cell. 165:139-52. https://doi.org/10.1016/j.cell.2016.02.034
A.J. Pagán, C-T. Yang, J. Cameron, L. E. Swaim, F. Ellett, G. J. Lieschke, L. Ramakrishnan 2015. Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment. Cell Host Microbe 18. 15-26 https://doi.org/10.1016/j.chom.2015.06.008
Cambier CJ, Falkow S, Ramakrishnan L. Host evasion and exploitation schemes of Mycobacterium tuberculosis. Cell. 2014 Dec 18;159(7):1497-509. doi: 10.1016/j.cell.2014.11.024. Review. PubMed PMID: 25525872.
Pagán AJ, Ramakrishnan L. Immunity and Immunopathology in the Tuberculous Granuloma. Cold Spring Harb Perspect Med. 2014 Nov 6. pii: a018499. doi: 10.1101/cshperspect.a018499. [Epub ahead of print] PubMed PMID: 25377142.
Patton EE, Dhillon P, Amatruda JF, Ramakrishnan L. Spotlight on zebrafish: translational impact. Dis Model Mech. 2014 Jul;7(7):731-3. doi: 10.1242/dmm.017004. PubMed PMID: 24973741; PubMed Central PMCID: PMC4073261.
Ramakrishnan L. The zebrafish guide to tuberculosis immunity and treatment. Cold Spring Harb Symp Quant Biol. 2013;78:179-92. doi: 10.1101/sqb.2013.78.023283. Epub 2014 Mar 18. PubMed PMID: 24643219.
Adams KN, Szumowski JD, Ramakrishnan L. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis. 2014 Aug 1;210(3):456-66. doi: 10.1093/infdis/jiu095. Epub 2014 Feb 14. PubMed PMID: 24532601; PubMed Central PMCID: PMC4110457.
Cambier CJ, Takaki KK, Larson RP, Hernandez RE, Tobin DM, Urdahl KB, Cosma CL, Ramakrishnan L. Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids. Nature. 2014 Jan 9;505(7482):218-22. doi: 10.1038/nature12799. Epub 2013 Dec 15. PubMed PMID: 24336213; PubMed Central PMCID: PMC3961847.
Tobin DM, Roca FJ, Ray JP, Ko DC, Ramakrishnan L. An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection. PLoS One. 2013 Jul 11;8(7):e67828. doi: 10.1371/journal.pone.0067828. Print 2013. PubMed PMID: 23874453; PubMed Central PMCID: PMC3708926.
Takaki K, Davis JM, Winglee K, Ramakrishnan L. Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish. Nat Protoc. 2013 Jun;8(6):1114-24. doi: 10.1038/nprot.2013.068. Epub 2013 May 16. PubMed PMID: 23680983; PubMed Central PMCID: PMC3919459.
Roca FJ, Ramakrishnan L. TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species. Cell. 2013 Apr 25;153(3):521-34. doi: 10.1016/j.cell.2013.03.022. Epub 2013 Apr 11. PubMed PMID: 23582643; PubMed Central PMCID: PMC3790588.
Ramakrishnan L. An interview with Lalita Ramakrishnan. Trends Pharmacol Sci. 2013 Apr;34(4):197. doi: 10.1016/j.tips.2013.02.005. PubMed PMID: 23566316.
Ramakrishnan L. Looking within the zebrafish to understand the tuberculous granuloma. Adv Exp Med Biol. 2013;783:251-66. doi: 10.1007/978-1-4614-6111-1_13. Review. PubMed PMID: 23468113.
Szumowski JD, Adams KN, Edelstein PH, Ramakrishnan L. Antimicrobial efflux pumps and Mycobacterium tuberculosis drug tolerance: evolutionary considerations. Curr Top Microbiol Immunol. 2013;374:81-108. doi: 10.1007/82_2012_300. PubMed PMID: 23242857; PubMed Central PMCID: PMC3859842.
Berg RD, Ramakrishnan L. Insights into tuberculosis from the zebrafish model. Trends Mol Med. 2012 Dec;18(12):689-90. doi: 10.1016/j.molmed.2012.10.002. Epub 2012 Oct 17. PubMed PMID: 23084762.
Yang CT, Cambier CJ, Davis JM, Hall CJ, Crosier PS, Ramakrishnan L. Neutrophils exert protection in the early tuberculous granuloma by oxidative killing of mycobacteria phagocytosed from infected macrophages. Cell Host Microbe. 2012 Sep 13;12(3):301-12. doi: 10.1016/j.chom.2012.07.009. PubMed PMID: 22980327; PubMed Central PMCID: PMC3638950.
Takaki K, Cosma CL, Troll MA, Ramakrishnan L. An in vivo platform for rapid high-throughput antitubercular drug discovery. Cell Rep. 2012 Jul 26;2(1):175-84. doi: 10.1016/j.celrep.2012.06.008. Epub 2012 Jul 20. PubMed PMID: 22840407; PubMed Central PMCID: PMC3433401.
Ramakrishnan L. Revisiting the role of the granuloma in tuberculosis. Nat Rev Immunol. 2012 Apr 20;12(5):352-66. doi: 10.1038/nri3211. Review. PubMed PMID: 22517424.
Tobin DM, Roca FJ, Oh SF, McFarland R, Vickery TW, Ray JP, Ko DC, Zou Y, Bang ND, Chau TT, Vary JC, Hawn TR, Dunstan SJ, Farrar JJ, Thwaites GE, King MC, Serhan CN, Ramakrishnan L. Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell. 2012 Feb 3;148(3):434-46. doi: 10.1016/j.cell.2011.12.023. PubMed PMID: 22304914; PubMed Central PMCID: PMC3433720.
Adams KN, Takaki K, Connolly LE, Wiedenhoft H, Winglee K, Humbert O, Edelstein PH, Cosma CL, Ramakrishnan L. Drug tolerance in replicating mycobacteria mediated by a macrophage-induced efflux mechanism. Cell. 2011 Apr 1;145(1):39-53. doi: 10.1016/j.cell.2011.02.022. Epub 2011 Mar 3. Erratum in: Cell. 2011 Apr 1;145(1):159. PubMed PMID: 21376383; PubMed Central PMCID: PMC3117281.
Tobin DM, Vary JC Jr, Ray JP, Walsh GS, Dunstan SJ, Bang ND, Hagge DA, Khadge S, King MC, Hawn TR, Moens CB, Ramakrishnan L. The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans. Cell. 2010 Mar 5;140(5):717-30. doi: 10.1016/j.cell.2010.02.013. PubMed PMID: 20211140; PubMed Central PMCID: PMC2907082.
Traag BA, Driks A, Stragier P, Bitter W, Broussard G, Hatfull G, Chu F, Adams KN, Ramakrishnan L, Losick R. Do mycobacteria produce endospores? Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):878-81. doi: 10.1073/pnas.0911299107. Epub 2009 Dec PubMed PMID: 20080769; PubMed Central PMCID: PMC2818926.
Volkman HE, Pozos TC, Zheng J, Davis JM, Rawls JF, Ramakrishnan L. Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium. Science. 2010 Jan 22;327(5964):466-9. doi: 10.1126/science.1179663. Epub 2009 Dec 10. PubMed PMID: 20007864; PubMed Central PMCID: PMC3125975.
Brannon MK, Davis JM, Mathias JR, Hall CJ, Emerson JC, Crosier PS, Huttenlocher A, Ramakrishnan L, Moskowitz SM. Pseudomonas aeruginosa Type III secretion system interacts with phagocytes to modulate systemic infection of zebrafish embryos. Cell Microbiol. 2009 May;11(5):755-68. doi: 10.1111/j.1462-5822.2009.01288.x. Epub 2009 Jan 15. PubMed PMID: 19207728; PubMed Central PMCID: PMC2933946.
Davis JM, Ramakrishnan L. The role of the granuloma in expansion and dissemination of early tuberculous infection. Cell. 2009 Jan 9;136(1):37-49. doi: 10.1016/j.cell.2008.11.014. PubMed PMID: 19135887; PubMed Central PMCID: PMC3134310.
Cosma CL, Humbert O, Sherman DR, Ramakrishnan L. Trafficking of superinfecting Mycobacterium organisms into established granulomas occurs in mammals and is independent of the Erp and ESX-1 mycobacterial virulence loci. J Infect Dis. 2008 Dec 15;198(12):1851-5. doi: 10.1086/593175. PubMed PMID: 18983252; PubMed Central PMCID: PMC2644660.
Cosma CL, Swaim LE, Volkman H, Ramakrishnan L, Davis JM. Zebrafish and frog models of Mycobacterium marinum infection. Curr Protoc Microbiol. 2006 Dec;Chapter 10:Unit 10B.2. doi: 10.1002/0471729256.mc10b02s3. PubMed PMID: 18770575.
Clay H, Volkman HE, Ramakrishnan L. Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death. Immunity. 2008 Aug 15;29(2):283-94. doi: 10.1016/j.immuni.2008.06.011. PubMed PMID: 18691913; PubMed Central PMCID: PMC3136176.
Tobin DM, Ramakrishnan L. Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis. Cell Microbiol. 2008 May;10(5):1027-39. doi: 10.1111/j.1462-5822.2008.01133.x. Epub 2008 Feb 20. Review. PubMed PMID: 18298637.
Davis JM, Ramakrishnan L. “The very pulse of the machine”: the tuberculous granuloma in motion. Immunity. 2008 Feb;28(2):146-8. doi: 10.1016/j.immuni.2008.01.002. PubMed PMID: 18275827.
Clay H, Davis JM, Beery D, Huttenlocher A, Lyons SE, Ramakrishnan L. Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish. Cell Host Microbe. 2007 Jul 12;2(1):29-39. PubMed PMID: 18005715; PubMed Central PMCID: PMC3115716.
Connolly LE, Edelstein PH, Ramakrishnan L. Why is long-term therapy required to cure tuberculosis? PLoS Med. 2007 Mar;4(3):e120. PubMed PMID: 17388672; PubMed Central PMCID: PMC1831743.
Swaim LE, Connolly LE, Volkman HE, Humbert O, Born DE, Ramakrishnan L. Mycobacterium marinum infection of adult zebrafish causes caseating granulomatous tuberculosis and is moderated by adaptive immunity. Infect Immun. 2006 Nov;74(11):6108-17. Erratum in: Infect Immun. 2007 Mar;75(3):1540. PubMed PMID: 17057088; PubMed Central PMCID: PMC1695491.
Cosma CL, Klein K, Kim R, Beery D, Ramakrishnan L. Mycobacterium marinum Erp is a virulence determinant required for cell wall integrity and intracellular survival. Infect Immun. 2006 Jun;74(6):3125-33. PubMed PMID: 16714540; PubMed Central PMCID: PMC1479242.
Clay H, Ramakrishnan L. Multiplex fluorescent in situ hybridization in zebrafish embryos using tyramide signal amplification. Zebrafish. 2005;2(2):105-11. doi: 10.1089/zeb.2005.2.105. PubMed PMID: 18248170
Volkman HE, Clay H, Beery D, Chang JC, Sherman DR, Ramakrishnan L. Tuberculous granuloma formation is enhanced by a mycobacterium virulence determinant. PLoS Biol. 2004 Nov;2(11):e367. Epub 2004 Oct 26. PubMed PMID: 15510227; PubMed Central PMCID: PMC524251.
Pozos TC, Ramakrishnan L. New models for the study of Mycobacterium-host interactions. Curr Opin Immunol. 2004 Aug;16(4):499-505. Review. Erratum in: Curr Opin Immunol. 2005 Feb;17(1):95. Ramakrishan, Lalita [corrected to Ramakrishnan,Lalita]. PubMed PMID: 15245746.
Cosma CL, Humbert O, Ramakrishnan L. Superinfecting mycobacteria home to established tuberculous granulomas. Nat Immunol. 2004 Aug;5(8):828-35. Epub 2004 Jun 27. PubMed PMID: 15220915.
Cosma CL, Sherman DR, Ramakrishnan L. The secret lives of the pathogenic mycobacteria. Annu Rev Microbiol. 2003;57:641-76. Review. PubMed PMID: 14527294.
Davis JM, Clay H, Lewis JL, Ghori N, Herbomel P, Ramakrishnan L. Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos. Immunity. 2002 Dec;17(6):693-702. PubMed PMID: 12479816.
Chan K, Knaak T, Satkamp L, Humbert O, Falkow S, Ramakrishnan L. Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infection. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3920-5. Epub 2002 Mar 12. PubMed PMID: 11891270; PubMed Central PMCID: PMC122624.
Bouley DM, Ghori N, Mercer KL, Falkow S, Ramakrishnan L. Dynamic nature of host-pathogen interactions in Mycobacterium marinum granulomas. Infect Immun. 2001 Dec;69(12):7820-31. PubMed PMID: 11705964; PubMed Central PMCID: PMC98878.
Ramakrishnan L. Images in clinical medicine. Mycobacterium marinum infection of the hand. N Engl J Med. 1997 Aug 28;337(9):612. PubMed PMID: 9271484.
Ramakrishnan L, Valdivia RH, McKerrow JH, Falkow S. Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens). Infect Immun. 1997 Feb;65(2):767-73. PubMed PMID: 9009340; PubMed Central PMCID: PMC176123.
Valdivia RH, Hromockyj AE, Monack D, Ramakrishnan L, Falkow S. Applications for green fluorescent protein (GFP) in the study of host-pathogen interactions. Gene. 1996;173(1 Spec No):47-52. PubMed PMID: 8707055.
Ramakrishnan L, Falkow S. Mycobacterium marinum persists in cultured mammalian cells in a temperature-restricted fashion. Infect Immun. 1994 Aug;62(8):3222-9. PubMed PMID: 8039892; PubMed Central PMCID: PMC302949.