Focal osteoporosis defects play a key role in hip fracture
Our paper based on work funded by Arthritis Research UK and the Cambridge NIHR Biomedical Research Centre was accepted by the journal BONE in November 2016. The graphical abstract is available here. The result of ongoing collaboration with Graham Treece and Andrew Gee in engineering and Jan Stepan in Prague, we now show that;
- Hip fractures involve distinct patterns of focal osteoporosis in the proximal femur, since there was less cortical and trabecular bone in those key areas in patients scanned just after admission with fracture
- Focal osteoporosis determined the fracture location
Defects can be detected using ordinary clinical CT scans of patients.
- Poole KE, Skingle L, Gee AH, Turmezei TD, Johannesdottir F, Blesic K, Rose C, Vindlacheruvu M, Donell S, Vaculik J, Dungl P, Horak M, Stepan JJ, Reeve J, Treece GM. Focal osteoporosis defects play a key role in hip fracture. 2017;94:124-34. https://www.ncbi.nlm.nih.gov/pubmed/27777119
The PHOENIX trial
Picking up Hidden Osteoporosis Effectively during Normal CT Imaging without additional X-rays (links to the idea here). Opportunistic screening for osteoporosis during routine CT was selected from over 600 applications to receive NHS Innovation funding. It means that we can diagnose and treat osteoporosis in the routine NHS CT imaging service while still conducting our research programme. Polly Barnes is now routinely diagnosing osteoporosis in men and women undergoing clinical CT for other reasons. Daniel Chappell will join our team later in 2016 to expand the capability of this service. One in every five high risk patients tested turns out to have previously unrecognised osteoporosis in the spine, hip or both sites. We are now seeking funding to conduct a large trial of routine opportunistic screening. Click here for an interesting article in the magazine Science explaining translational research.
Links with Japan
Dr Hiroshige Sano who is an Orthopaedic surgeon and Rheumatologist and was recently awarded his PhD from Niigata University, Japan, Hiro joins us as a Research Associate working on the histological basis of bone modelling, building on his work uncovering the mini-modelling phenomenon.
Adrian J Crisp PhD Studentship
Ilya Burkov, MSc Nanomedicine, BEng Medical Engineering, was awarded the Adrian J Crisp PhD studentship and will be with us for 3 years. Ilya joined us from Swansea University, his MSc involving the study of cellular mediators in osteoarthritis.