Dr Tom Turmezei
An algorithm to monitor the joints of patients with arthritis, which could change the way that the severity of the condition is assessed, has been developed by a team of engineers, physicians and radiologists led by the University of Cambridge. The technique, developed during a Wellcome PhD studentship by Dr Tom Turmezei and colleagues detects tiny changes in arthritic joints, and could enable greater understanding of how osteoarthritis develops and allow the effectiveness of new treatments to be assessed more accurately, without the need for invasive tissue sampling. The results are published in the journal Scientific Reports.
Focal osteoporosis defects play a key role in hip fracture
Our paper based on work funded by Arthritis Research UK and the Cambridge NIHR Biomedical Research Centre was accepted by the journal BONE in November 2016. The graphical abstract is available here. The result of ongoing collaboration with Graham Treece and Andrew Gee in engineering and Jan Stepan in Prague, we now show that;
- Hip fractures involve distinct patterns of focal osteoporosis in the proximal femur, since there was less cortical and trabecular bone in those key areas in patients scanned just after admission with fracture
- Focal osteoporosis determined the fracture location
Defects can be detected using ordinary clinical CT scans of patients.
- Poole KE, Skingle L, Gee AH, Turmezei TD, Johannesdottir F, Blesic K, Rose C, Vindlacheruvu M, Donell S, Vaculik J, Dungl P, Horak M, Stepan JJ, Reeve J, Treece GM. Focal osteoporosis defects play a key role in hip fracture. 2017;94:124-34. https://www.ncbi.nlm.nih.gov/pubmed/27777119
The PHOENIX trial
Picking up Hidden Osteoporosis Effectively during Normal CT Imaging without additional X-rays (links to the idea here). Opportunistic screening for osteoporosis during routine CT was selected from over 600 applications to receive NHS Innovation funding. It means that we can diagnose and treat osteoporosis in the routine NHS CT imaging service while still conducting our research programme. We are now routinely diagnosing osteoporosis in men and women undergoing clinical CT for other reasons. One in every five high risk patients tested turns out to have previously unrecognised osteoporosis in the spine, hip or both sites. We are now seeking funding to conduct a large trial of routine opportunistic screening. Click here for an interesting article in the magazine Science explaining translational research.
Links with Japan
Dr Hiroshige Sano who is an Orthopaedic surgeon and Rheumatologist and was recently awarded his PhD from Niigata University, Japan, Hiro joins us as a Research Associate working on the histological basis of bone modelling, building on his work uncovering the mini-modelling phenomenon.
Adrian J Crisp PhD Studentship
Ilya Burkov, MSc Nanomedicine, BEng Medical Engineering, was awarded the Adrian J Crisp PhD studentship, and spent four years working on predicting osteoarthritis with cortical bone mapping.