The Mahadeva group has a long standing interest in mechanisms of pulmonary inflammation in COPD, particularly in those with alpha-1 antitrypsin deficiency. Ravi Mahadeva is a previous recipient of the European Respiratory society COPD research award 2004 and a Wellcome Trust Advanced Fellowship.

Studies with in vivo and cellular models are used to explore the link between conformational transitions of antitrypsin and pulmonary inflammation with a view to assessing new treatments.