An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation. Ingemarsdotter CK, Zeng J, Long Z, Lever AML, Kenyon JC Retrovirology. 2018 Mar 14;15(1):25
Expression of Herpes Simplex Virus Thymidine Kinase/Ganciclovir by RNA Trans-Splicing Induces Selective Killing of HIV-Producing Cells. Ingemarsdotter CK, Poddar S, Mercier S, Patzel V, Lever AML. Mol Ther Nucleic Acids. 2017 Jun 16;7:140-154.
Evidence that the endosomal sorting complex required for transport-II (ESCRT-II) is required for efficient human immunodeficiency virus-1 (HIV-1) production. Meng B, Ip NC, Prestwood LJ, Abbink TE, Lever AM. Retrovirology. 2015 Aug 14;12:72.
Identification of RNA helicases in human immunodeficiency virus 1 (HIV-1) replication – a targeted small interfering RNA library screen using pseudotyped and WT HIV-1. Williams CA, Abbink TE, Jeang KT, Lever AM. J Gen Virol. 2015 Jun;96(Pt 6):1484-9
Kenyon JC, Tanner SJ, Legiewicz M, Phillip PS, Rizvi TA, Le Grice SFJ, Lever AM. SHAPE Analysis of the FIV Leader RNA reveals a structural switch potentially controlling Viral Packaging and Genome Dimerization Nucleic Acids Res. 2011 39(15):6692-704