Gastroenterology and Hepatology

Research

Research in this Division focuses on immunity and inflammation and its consequences, and the genetic underpinning of gastrointestinal diseases.

Professor Kaser’s group has a research focus on inflammation at mucosal body surfaces and inflammatory bowel disease (IBD).  Specifically his group investigates the role of the intestinal epithelium at the interface between the intestinal microbiota and the sterile host environment, with a particular interest in the epithelium’s endoplasmic reticulum stress response.

Dr Parkes investigates the genetic basis of IBD through genome-wide association studies performed in collaboration with the Wellcome Trust Sanger Centre.  He has also been leading the International IBD Genetics consortium’s GWAS meta-analysis, which revealed almost 100 distinct genetic loci associated with IBD.

 Dr Fitzgerald (based in the MRC Cancer Cell Unit) investigates the molecular pathogenesis and progression of Barrett’s disease and oesophageal cancer to provide tools for early diagnosis, accurate prognostication and therapy which can be applied to clinical practice.

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