Co-investigator, Professor A. Lever

The work of this laboratory centres on aspects of the molecular biology of rotaviruses (RVs):

1. Interaction of RV proteins with cellular proteins and organelles during viral replication,
2. Structures and structure-function analyses of RV RNAs,
3. Experiments to establish a plasmid only-based reverse genetics system for RVs. [Read More...]

Cheung W, Gill M, Esposito A, Kaminski CF, Courousse N, Chwetzoff S, Trugnan G, Keshavan N, Lever A, Desselberger U. Rotaviruses associate with cellular lipid droplet components to replicate in viroplasms, and compounds disrupting or blocking lipid droplets inhibit viroplasm formation and viral replication. J Virol. 2010 Jul;84(13):6782-98.

Arnoldi F, Campagna M, Eichwald C, Desselberger U, Burrone OR. The Interaction of the rotavirus polymerase VP1 with the non-structural protein NSP5 is stronger than with NSP2. J Virol 2007; 81: 2128-2137.

Campagna M, Budini M,  Arnoldi F, Desselberger U, Allende JE, Burrone OR. Impaired hyperphosphorylation of rotavirus NSP5 in cells depleted  of casein kinase 1α is associated with the formation of viroplasms with altered morphology and a moderate decrease in virus replication. J Gen Virol 2007; 88: 2800-2810.

Desselberger U, Manktelow E, Li W, Cheung W, Iturriza-Gomara M, Gray J. Rotaviruses and rotavirus vaccines.  Brit Med Bull 2009; 90: 37-51. [Read More...]