My research has focused on the role of neutrophil and eosinophil granulocytes as mediators of tissue injury in respiratory disease. I have a particular interest in the phenomenon of neutrophil priming, which up-regulates the injurious potential of these cells. My group also studies the mechanisms of glucocorticoid resistance in asthma, and the distribution and fate of eosinophils in health and in allergic disease. [Read More...]
McGovern NN, Cowburn AS, Porter L, Walmsley SR, Summers C, Thompson AA, Anwar S, Willcocks LC, Whyte MK, Chilvers ER,* Condliffe AM.* Hypoxia selectively inhibits respiratory burst activity and killing of Staphylococcus aureus in human neutrophils. J Immunol 2011;186(1):453-63. *joint senior author.
Condliffe AM*, Suire S*, Ferguson GJ, Ellson CD, Guillou H, Davidson K, Welch H, Coadwell J, Turner M, Chilvers ER, Hawkins PT, Stephens L. Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils. Nat Cell Biol 2006; 8:1303-9. * Joint first authors.
Condliffe AM, Davidson K, Anderson KE, Ellson CD, Crabbe T, Okkenhaug K, Vanhaesebroeck B, Turner M, Webb L, Wymann MP, Hirsch E, Ruckle T, Camps M, Rommel C, Jackson SP, Chilvers ER, Stephens LR, Hawkins PT. Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 2005; 106:1432-40. [Read More...]