My research has focused on the role of neutrophil and eosinophil granulocytes as mediators of tissue injury in respiratory disease. Defects in innate and adaptive immunity lead to infection with a predilection for the respiratory tract, yet granulocytic infiltration underpins a range of inflammatory and allergic respiratory diseases such as chronic obstructive pulmonary disease, acute lung injury and asthma
Angulo-Herrera I, Vadas O, Garson F, Banham-Hall E, Plagnol V, Leahy TR, Baxendale H, Coulter T, Curtis J, Wu C, Blake-Palmer K, Perisic O, Smith D, Maes, M, Fiddler C, Juss J, Cilliers D, Markelj G, Chandra A, Farmer G, Kielkowska A, Clark J, Kracker S, Debre M, Picard C, Pellier I, Jabaco N, Morris JA, Fischer A, Stephens L, Hawkins P, Barrett JC, Abinun M, Clatworthy M, Durandy A, Doffinger R, Chilvers ER, Cant AJ, Kumararatne D, Okkenhaug K, Williams RL, Condliffe AM,* Nejentsev S*. An inherited PIK3CD mutation increases phosphoinositide 3-kinase delta activity and predisposes to recurrent respiratory infections and bronchiectasis. Science 2013; 342:866-71.
Farahi N, Singh NR, Heard S, Summers C, Simmonds RP, Solanki SK, Solanki K, Kottekkattu B, Ruparelia, Peters AM*, Chilvers ER*, and Condliffe AM*. Use of 111-Indium-labelled autologous eosinophils to establish the in vivo kinetics of human eosinophils in healthy subjects. Blood 2012; 120:4068-71.
McGovern NN, Cowburn AS, Porter L, Walmsley SR, Summers C, Thompson AA, Anwar S, Willcocks LC, Whyte MK, Chilvers ER,* Condliffe AM.* Hypoxia selectively inhibits respiratory burst activity and killing of Staphylococcus aureus in human neutrophils. J Immunol 2011;186(1):453-63. *joint senior author.