Aravani D, Foote K, Figg N, Finigan A, Uryga AK, Clarke MCH, Bennett MR. Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells. Apoptosis. 2020; Jul 5. doi: 10.1007/s10495-020-01622-4. Chan JNE, Humphry M, Kitt LL, Krzyzanska D. Filbey KJ, Bennett MR, Clarke MCH. Cell surface IL-1α trafficking is specifically inhibited by interferon-γ, and associates with the membrane via IL-1R2 and GPI anchors. Eur J Immunol. 2020; 2020 May 24. doi: 10.1002/eji.201948521. Cassidy L, Young ARJ, Young CNJ, Soilleux EJ, Fielder E, Weigand BM, Brais R, Wiggins KA, Clarke MCH, Jurk D, Passos JF, Narita, M. Temporal inhibition of autophagy reveals segmental reversal of aging with increased cancer risk. Nature Comms. 2020; 11, 307. Burzynski LC, Clarke MCH. Death Is Coming and the clot thickens, as pyroptosis feeds the fire. Immunity. 2019; 50, 1339-1341. Burzynski LC, Humphry M, Wiggins KA, Summers C, Tatham KC, Martin PB, Bennett MR, Clarke MCH. The coagulation and immune system are directly linked through the activation of interleukin-1α by thrombin. Immunity. 2019; 50, 1–10, April 16. Wiggins KA, Parry AJ, Cassidy L, Webster SJ, Humphry M, Goodall JC, Narita M, Clarke MCH. IL-1α cleavage by inflammatory caspases of the non-canonical inflammasome controls the senescence-associated secretory phenotype. Aging Cell. 2019. e12946. Basatemur B, *Jorgensen H, *Clarke MCH, Bennett M, Mallat Z. Vascular smooth muscle cells in atherosclerosis. Nature Revs Cardio. 2019 10.1038/s41569-019-0227-9. Wiggins KA, Clarke MCH. Senescence utilises inflammatory caspases to drive the SASP. Aging. 2019; 11(12): 3891–3892. Burzynski LC, Pugh N, Clarke MCH. Platelet isolation and activation assays. Bio-protocol. 2019. 9(20): e3405. Bennett MR, Clarke MCH. Killing the old: cell senescence in atherosclerosis. Nature Revs Cardio. 2017; 14, 8-9. Wang J, Uryga AK, Reinhold J, Figg N, Baker L, Finigan A, Gray K, Kumar S, Clarke MCH, Bennett M. Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque Vulnerability. Circulation. 2015; 132(20):1909-19. Burzynski LC, Humphry M, Bennett MR, Clarke MCH. Interleukin-1α activity in necrotic endothelial cells is controlled by caspase-1 cleavage of interleukin-1 receptor-2; implications for allograft rejection. J Biol Chem 2015; Aug 31 ePub. Gardner SE, Humphry M, Bennett MR, Clarke MCH. Senescent vascular smooth muscle cells drive inflammation through an interleukin-1α-dependent senescence-associated secretory phenotype. ATVB. 2015; 35(9):1963-74. Maguire JJ, Jones KL, Kuc RE, Clarke MCH, Bennett MR, Davenport AP. The CCR5 chemokine receptor mediates vasoconstriction and stimulates intimal hyperplasia in human vessels in vitro. Cardiovas Res. 2013;101(3):513-21 Zhang Y, Humphry M, Maguire JJ, Bennett MR, Clarke MCH: Intracellular IL-1 receptor 2 binding prevents cleavage and activity of IL-1α, controlling necrosis-induced sterile inflammation. Immunity. 2013; 38:2, 285. Clarke MCH, Talib S, Figg N, Bennett MR: Vascular smooth muscle cell apoptosis induces IL-1-directed inflammation; effects of hyperlipidemia-mediated inhibition of phagocytosis. Circ Res. 2010; 106(2):363-72. Clarke, MCH, Littlewood, TD, Figg, N, Maguire, JJ, Davenport, AP, Goddard, M, Bennett, MR. Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis, and promotes calcification and medial degeneration. Circ Res. 2008; 102(12):1529-1538. Clarke, MCH, Figg, N, Maguire, JJ, Davenport, AP, Goddard, M, Littlewood, TD, Bennett, MR. Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis. Nature Med. 2006; 12:1075-1080. Clarke MCH, Savill J, Jones DB, Noble BS, Brown SB: Compartmentalised progenitor cell apoptosis generates functional platelets committed to caspase-independent death. J. Cell. Biol. 2003; 160(4): 577-87. Clarke MCH, Brown SB, Magowan L, Sanderson H, Savill J: Constitutive death of platelets leading to scavenger receptor-mediated phagocytosis; a caspase-independent cell clearance program. J. Biol. Chem. 2000; 275: 5987-5996. Bennett MR, Yu H, Clarke MCH: Signalling from dead cells drives inflammation and vessel remodelling. Vascul Pharmacol. 2012; 56:187-92. Zheng Y, Gardner SE, Clarke MCH: Cell Death, Damage-Associated Molecular Patterns, and Sterile Inflammation in Cardiovascular Disease. ATVB. 2011; 31:2781-2786. Yu H, Clarke MCH, Figg N, Littlewood T, Bennett MR: Smooth muscle cell apoptosis promotes vessel remodeling, via activation of cell migration, proliferation and collagen synthesis. ATVB. 2011; 31:2402-2409. Calvert PA, Liew TV, Gorenne I, Clarke MCH, Costopoulos C, Obaid DR, O’Sullivan M, Shapiro LM, McNab DC, Densem CG, Schofield PM, Braganza D, Clarke SC, Ray KK, West NEJ, Bennett MR: Leukocyte Telomere Length Is Associated With High-Risk Plaques on Virtual Histology Intravascular Ultrasound and Increased Proinflammatory Activity. ATVB. 2011; 31(9):2157-64. Yu H, Stoneman V, Clarke MCH, Figg N, Xin HB, Kotlikoff M, Littlewood T, Bennett MR: Bone Marrow-Derived Smooth Muscle-Like Cells Are Infrequent in Advanced Primary Atherosclerotic Plaques but Promote Atherosclerosis. ATVB. 2011;31:1291-1299. Clarke MCH, Bennett MR. Cause or Consequence: What Does Macrophage Apoptosis Do in Atherosclerosis? ATVB. 2009; 29:153. Clarke, MCH, Bennett, MR and Littlewood, TD. Cell death in the cardiovascular system. Heart 2007; 93; 659-664. Clarke, MCH, Bennett, MR. Defining the role of vascular smooth muscle cell apoptosis in atherosclerosis. Cell Cycle. 2006; 20: 2329-31. Clarke MCH, Bennett MR. The Emerging Role of Vascular Smooth Muscle Cell Apoptosis in Atherosclerosis and Plaque Stability. Am J Nephrol. 2006; 26(6):531-535. Wickenden JA, Clarke MCH, Rossi AG, Rahman I, Faux SP, Donaldson K, MacNee W. Cigarette smoke prevents apoptosis through inhibition of caspase activation and induces necrosis. Am. J. Respir. Cell. Mol. Biol. 2003; 29(5): 562-570. Clarke MCH, Bennett, MR. Defining the role of vascular smooth muscle cell apoptosis in atherosclerosis. Cell Cycle. 2006; 20: 2329-31. Clarke MCH, Bennett MR. The Emerging Role of Vascular Smooth Muscle Cell Apoptosis in Atherosclerosis and Plaque Stability. Am J Nephrol. 2006; 26(6):531-535.
