My laboratory studies homeostatic abnormalities in autoimmune disease. We have developed novel methodologies for quantifying the rates of production and destruction of cells and macromolecules in cell culture and in the living body, using nonradioactive isotope labelling and mass spectrometry. We are using this approach to understand the dynamics of antigen presentation and its role as a link between polymorphisms in the major histocompatibility complex (MHC) and risk of autoimmune arthritis.

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