Salary: £28,695-£37,394 pa
Closing date: 1 January 2015
We have a postdoctoral position available in the laboratory of Professor Yorgo Modis in the Department of Medicine at the University of Cambridge to study cell entry and innate immune recognition of enveloped RNA viruses. This post is funded by the Wellcome Trust.
We seek a highly motivated individual to study the mechanisms of cell entry and innate immune recognition of enveloped RNA viruses from the Flaviviridae and/or Bunyaviridae families using a combination of biophysical and biochemical approaches.
A PhD in the biological, biochemical or biomedical sciences is desirable, as well as relevant research experience in molecular biology, protein biochemistry and eukaryotic cell culture, and at least one first-author research article in a major peer-reviewed journal.
You should also have research experience in macromolecular structure determination, particularly by electron microscopy or X-ray crystallography. Alternatively, research experience in high-resolution imaging by fluorescence light microcopy, in single-molecule approaches, in mass spectrometry, or in virological or immunological assays.
The overarching goal of the Modis lab’s research program is to gain a mechanistic understanding at the molecular level of how important pathogens interact with their host cells during infection. We seek to understand: How do enveloped viruses assemble and recognize host cells? How do enveloped viruses deliver their genome into the cytoplasm? What are the evolutionary origins of the genes that drive virus entry? How are innate immune responses to viral nucleic acids generated, amplified and regulated? We employ a diverse set of complementary approaches including X-ray crystallography, electron microscopy, solution biophysics, fluorescence microscopy and cell biological approaches to understand the mechanisms that underlie these processes in molecular-level detail. Our projects have important potential applications in global health.
The Modis Laboratory is part of the new University Research Unit within the Laboratory of Molecular Biology (LMB). It benefits from the unique scientific environment and infrastructure of the MRC-LMB, and from direct links to the Infectious Disease and Immunology community within the Department of Medicine.
Informal enquiries are welcomed, and should be directed to Professor Modis at firstname.lastname@example.org
Closing Date: Please note the closing time for applications is 1st January 2015.
Fixed-term: The funds for this post are available for 5 years in the first instance.
To apply online for this vacancy, please click on the ‘Apply’ button below. This will route you to the University’s Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.
Please quote reference RC04283 on your application and in any correspondence about this vacancy.
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