Employment opportunities within the Department of Medicine

Research Associate

Salary: £28,695-£37,395

Closing date: 2 December 2014

Reference: RC04767


We are looking to recruit a motivated, full-time post-doctoral Research Associate to join the group of Professor Timothy Cox in the Department of Medicine, Cambridge University. The lab is located in the laboratory wing of Addenbrooke’s hospital on the Cambridge Biomedical campus.

Our research is focused on the molecular mechanisms of cell death and neuroinflammation in Krabbe disease, principally using a genetically coherent disease model. Krabbe disease causes an acute demyelinating neurodegeneration of white matter and myelinated nerves with loss of oligodendroglia; inflammatory changes are prominent.

We seek to determine whether blocking key determinants of necroinflammation ameliorates the effects of Krabbe disease in the nervous system with improved neurological function and survival. We will also seek to investigate whether gene- or stem-cell transfer gives greater benefit if inopportune necroptosis can be prevented.

Experimental studies with authentic models of Krabbe disease and genetic crossing with other strains lacking key components required for necro-inflammatory cell death processes will be undertaken. We will determine survival measures and evaluate neurological function. Good husbandry and animal management will be essential.

The research will involve laboratory studies of sectioned nervous tissue: histology, biochemistry and immunohistochemistry as well as molecular cell biology. The lab uses a combination of molecular biology, immunohistochemistry and histomorphology: preference will be given to applicants with experience of comprehensive analytical techniques such as mass spectrometry. These will allow the evolution of the disease and it manifestations to be explored through studies of metabolic changes and bioactive sphingoid molecules.

The successful candidate must have experience with standard molecular biology techniques with some practical knowledge of cell-culture; genotyping by molecular analysis of DNA will be essential. The candidate will need to work as part of a small team at the outset, which can provide an opportunity for more independently-driven projects.

The ability to communicate effectively, work in a team and engage with scientific research directed to translational medicine is essential.

Informal enquiries are welcome and should be directed to Professor Timothy Cox FMedSci at ec432@medschl.cam.ac.uk or Dr Begoña Cachón-González PhD at mcb23@medschl.cam.ac.uk.

To apply online for this vacancy, please click on the ‘Apply’ button below. This will route you to the University’s Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Fixed-term: The funds for this post are available until 4 January 2017, in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.

Please quote reference RC04767 on your application and in any correspondence about this vacancy.

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Further information

Apply online