Gray, K, Kumar, K, Figg, N, Harrison, J, Baker, L, Mercer, J, Littlewood, TD, Bennett, MR. Effects of DNA damage in smooth muscle cells in atherosclerosis. Circ Res 2015. In press.

Patel, MN, Bernard, WG, Milev, NB, Figg, N, Hart, D, Cawthorn, WB, Virtue, S, Hegyi, K, Chu, Y, Griffin, JL, Akira, S, Vidal-Puig, AJ, Bennett, MR, Sethi, JK. Hematopoietic IκB kinase epsilon limits NLRP3 inflammasome priming, metabolic disease progression and atherosclerosis. Proc Natl Acad Sci USA 2015 ;112(2):506-11

Teng, Z, Brown, AJ, Calvert, PA, Parker, RA, Obaid, DR, Huang, Y, Hoole, SP, West, NEJ, Gillard, J, Bennett, MR. Coronary plaque structural stress is determined by plaque composition and subtype and increased in acute coronary syndrome: the BEACON I (Biomechanical Evaluation of Atheromatous COroNary Arteries) Study. Circulation Cardiovascular Imaging. 2014. 101; 513-521.

Tucka J, Yu, H, Gray, K, Figg, N, Maguire, J, Lam, B, Bennett, MR, Littlewood, TD. Akt1 regulates vascular smooth muscle cell apoptosis through Foxo3a and Apaf1 and protects against arterial remodeling and atherosclerosis. Arterioscler Thromb Vasc Biol. 2014. 34:2421-8.

 

Obaid, DR, Calvert,PA, Gopalan, D, Parker,RA, Hoole, SP, West, NEJ, Goddard,M, Rudd,JHF, Bennett, MR. Atherosclerotic plaque composition and classification identified by coronary CT: Assessment of CT- generated plaque maps compared with VH-IVUS and histology. Circulation Cardiovascular Imaging. 2013:6(5),655-664

Yu, E, Calvert^, PA, Mercer, JR, Kumar^, S, Harrison, J, Baker, L, Wang, J, Obaid, D, Figg, NL, Logan, A, West, N, Clarke, MCH, Vidal-Puig, A,Murphy, MP, Bennett, MR. Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes, and correlates with higher risk plaques in humans. Circulation. 2013 (128:702-12).

Zheng, Y, Humphry, M, Maguire, JJ, Bennett, MR, Clarke, MCH. Intracellular IL-1 receptor 2 binding prevents cleavage and activity of IL-1α, controlling necrosis-induced sterile inflammation. Immunity. 2013;38:285-295.

Gorenne, I, Kumar, S, Gray, K, Figg, N, Yu, H, Mercer, J, Bennett, MR. Vascular Smooth Muscle Cell Sirtuin 1 protects against DNA damage and inhibits atherosclerosis. Circulation. 2013;127(3):386-96

Calvert, PA, Obaid, DR, West, NEJ, Shapiro, LM, McNab, D, Densem, CG, Schofield, PM, Braganza, D, Clarke, SC, O’Sullivan, M, Ray, KK, Bennett, MR. Association between Virtual Histology intravascular ultrasound findings and adverse outcomes in patients with coronary artery disease: The VIVA (VH-IVUS in Vulnerable Atherosclerosis) Study. JACC Imaging. 2011. 4:894-901

Clarke MC, Talib S, Figg NL, Bennett MR (2010) Vascular smooth muscle cell apoptosis induces interleukin-1-directed inflammation: effects of hyperlipidemia-mediated inhibition of phagocytosis. Circ Res Feb 5; 106(2): 363-72

Clarke MCH, Littlewood TD, Figg N, Maguire JJ, Davenport AP, Goddard M, Bennett MR (2008) Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis, and promotes calcification and medial degeneration Circ Res. 102(12):1529-1538

Mahmoudi M, Gorenne I, Mercer J, Figg N, Littlewood TD, Bennett MR (2008) Statins utilise a novel NBS-dependent pathway to accelerate DNA repair in vascular smooth muscle cells Circ Res. 103;717-725

Stoneman V, Braganza D, Figg N, Mercer J, Lang R, Goddard M, Bennett MR (2007) Monocyte/macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaques Circ Res. 100(6):884-893

Clarke MC, Figg N, Maguire JJ, Davenport AP, Goddard M, Littlewood TD, Bennett MR (2006) Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis Nature Med. 12:1075-1080

Matthews C, Gorenne I, Scott S, Figg N, Kirkpatrick P, Ritchie A, Goddard M, Bennett MR Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress Circ Res. 2006 99(2):156-164

Mercer J, Figg N, Stoneman V, Braganza D and Bennett MR (2005) Endogenous p53 protects vascular smooth muscle cells from apoptosis and reduces atherosclerosis in ApoE knockout mice Circ Res. 96:667-74

Chan S-W, Hegyi L, Scott S, Cary N, Weissberg P, Bennett MR (2000) Sensitivity to Fas-mediated apoptosis is determined below receptor level in vascular smooth muscle cells Circ Res. 86:1038-1046

Bennett MR, Macdonald K, Chan SC, Luzio JP, Simari R and Weissberg PL (1998) Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis Science 282:290-293