Research paper accepted in principle (Jan 20, 2021), has been fully accepted for publication in Nature Communications Biology. Luke Thomas, Cinzia Esposito et al and Margaret Ashcroft. Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia.

Review accepted in Biochemical Society Transactions. Hasan Al-Habib and Margaret Ashcroft. CHCHD4 (MIA40) and the mitochondrial disulfide relay system (https://doi.org/10.1042/BST20190232).

Delighted the Ashcroft lab opens after lockdown, and group adjusting excellently to working differently due to COVID restrictions and social distancing.

Due to the COVID pandemic, the Ashcroft lab closed and the group continued to work remotely and meet virtually. During lockdown, Basma Greef was seconded to NHS clinical duties; Hasan Al-Habib worked with the COVID testing programme; Lucas Maddalena returned to Canada.

Prof Ashcroft was invited to speak at the Keystone meeting on Hypoxia: Molecules, Mechanisms and Disease (Colorado, USA), and gave a talk entitled ‘The Redox-Regulated Disulphide Relay System Controls Hypoxia Responses’, presenting work from the group including Hasan Al-Habib.