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The research in the Division has five main strands: The first involves physiological imaging in traumatic brain injury (TBI), at all stages, from ictus to late outcome. Positron emission tomography (PET) and magnetic resonance imaging (MRI) in the acute phase currently address novel mechanisms of energy failure, including diffusion hypoxia, inflammation, amyloid deposition, and mitochondrial dysfunction. Late MRI imaging is used to investigate mechanisms underlying neurocognitive deficits in TBI patients. A second strand focuses on the neuro-anatomical basis of coma and consciousness, both in pathological states, and in the controlled situation of sedation induced by anaesthetic agents. Third, the Division has a growing program in translational pain research, which focuses on analgesic discovery in collaboration with experimental pharmacology and clinical genetics. The methodologies we employ in pain research include early phase clinical trials, quantitative sensory testing, functional brain imaging and genotyping. Our fourth theme focuses on leukocyte biology in acute lung injury and critical illness, and aims to understand the role of host response in both injury and repair. Finally, a growing initiative in non-linear analysis of complex large datasets will make use of the implementation of the new eHospital system at Addenbrooke’s Hospital.
Hong YT, Veenith T, Dewar D, Outtrim JG, Mani V, Williams C, Pimlott S, Hutchinson PJ, Tavares A, Canales R, Mathis CA, Klunk WE, Aigbirhio FI, Coles JP, Baron JC, Pickard JD, Fryer TD, Stewart W, Menon DK. Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury. JAMA Neurol 2014;71(1):23-31. PubMed PMID: 24217171
Newcombe VF, Williams GB, Outtrim JG, Chatfield D, Abate GM, Geeraerts T, Manktelow A, Room H, Mariappen L, Hutchinson PJ, Coles JP, Menon DK. Microstructural basis of contusion expansion in traumatic brain injury: insights from diffusion tensor imaging. J Cereb Blood Flow Metab 2013;33(6):855-62. PubMed PMID: 23423189.
Veenith TV, Carter EL, Grossac J, Newcombe VF, Outtrim JG, Nallapareddy S, Lupson V, Correia MM, Mada MM, Williams GB, Menon DK, Coles JP. Use of diffusion tensor imaging to assess the impact of normobaric hyperoxia within at-risk pericontusional tissue after traumatic brain injury. J Cereb Blood Flow Metab 2014 (epub ahead of print)
Summers C, Singh NR, White JF, Mackenzie IM, Johnston A, Solanki C, Balan KK, Peters AM, Chilvers ER. Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome. Thorax 2014; 69(7):623-9. PubMed PMID: 24706039.
Newcombe VF, Outtrim JG, Chatfield DA, Manktelow A, Hutchinson PJ, Coles JP, Williams GB, Sahakian BJ, Menon DK. Parcellating the neuroanatomical basis of impaired decision-making in traumatic brain injury. Brain 2011; 134:759-68.
Stamatakis EA, Adapa RM, Absalom AR, Menon DK. Changes in resting neural connectivity during propofol sedation. PLoS One 2010; 5:e14224.
Janowitz T, Menon DK. Exploring new routes for neuroprotective drug development in traumatic brain injury. Sci Transl Med 2010; 2:27rv1.
Wheeler DW, Thompson AJ, Corletto F, Reckless J, Loke JC, Lapaque N, Grant AJ, Mastroeni P, Grainger DJ, Padgett CL, O’Brien JA, Miller NG, Trowsdale J, Lummis SC, Menon DK, Beech JS. Anaesthetic impairment of immune function is mediated via GABA(A) receptors. PLoS One 2011; 6:e17152.
Streamline tractography showing white matter images in a control subject, and below two patients in a vegetative state (from traumatic brain injury (TBI) and global ischaemia following cardiac arrest). Note the preferential loss of frontal and brain stem white matter in TBI. From Newcombe et al. J Neurol Neurosurg Psychiatry 2010; 81:552-61.