A heart attack occurs when a blood clot forms in a coronary artery depriving blood flow from a region of the heart, a condition termed ischemia. Current therapy is to reopen the artery but blood flow is seldom restored before a significant amount of the heart muscle has died. Because lost heart muscle cannot be regenerated the patient is left with a weakened heart and heart failure often occurs. Our research is directed toward identifying therapies that prevent cell death in ischemic heart and the subsequent development of heart failure.
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Grube K, Rüdebusch J, Xu Z, Böckenholt T, Methner C, Müller T, Cuello F, Zimmermann K, Yang X, Felix SB, Cohen MV, Downey JM, Krieg T. Evidence for an intracellular localization of the adenosine A2Breceptor in rat cardiomyocytes. Basic Res Cardiol. 106:385-96, 2011.